abstract: in a wide search program towards new and efficient antimicrobial agents, a series of 4-substituted-1,2,4-triazolidine-3,5-dione derivatives namely urazoles holding an alkyl moiety at position 4 have been synthesized and tested for their in vitro antibacterial and antifungal activities. the structures of these compounds have been investigated by spectral data. the synthesized compounds...

wide range of quinazolinone biological properties including: antibacterial, anticancer, and anti-inflammatory activities encouraged us to synthesis some fused quinazolinone derivatives. anthranilic acid was condensed with chloro acylchloride followed by dehydration to form the benzoxazinone intermediate; subsequent addition of an amine provided the fused quinazolinones. deoxyvasicinone which wa...

fractions obtained from partitioning of aerial methanolic extract of euphorbia aellenii with chloroform (e2), ethyl acetate (e3), n-butanol (e4) and water (e5) were investigated in vitro for their phytotoxicity, insecticidal, anti-leishmanial, cytotoxicity, antibacterial and antifungal activities. sample e2 appeared to have significant phytotoxic activity. in the insecticidal screening study on...

substituted 1, 2, 4- triazoles have shown multiple biological activities such as anti-inflammatory, anti fungal, etc. 5-mercapto triazoles were prepared from the potassium dithiocarbazinates. these triazoles were used for preparation of different derivatives by two different schemes. in the first scheme the mannich bases were prepared from 5- marcapto-s triazole quinazolines. the 5-marcato-s-tr...

background and objectives: dermatophytes possess a wide array of virulence factors and various antifungal susceptibility patterns which influence their pathogenesis in humans and animals. the aim of this study was to evaluate antifungal suscep- tibility and keratinase and proteinase activity of 49 dermatophyte strains from the genera microsporum , trichophyton and epidermophyton which were isol...

pyrazine derivatives are important class of compounds with diverse biological and cytotoxic activities and clinical applications. in this study, b3 p 86 / 6 – 31 + + g * was used to compute and map the molecular surface electrostatic potentials of a group of substituted amides of pyrazine-2-carboxylic acids to identify common features related to their subsequent cytotoxicities. several statisti...

background & aim: the purpose of present study was to examine and validate the folk's claim of inhalation of monechma ciliatum seeds powder by traditional african natives for cold and allergic conditions, so as to formulate a useful therapeutic agent to respiratory tract infections. experimental: different extracts were bio-assayed in vitro for their bioactivity to inhibit the growth of pat...

an endochitinase gene (chit36) was isolated from the biocontrol fungus trichoderma atroviride. chit36 was overexpressed under the camv35s constitutive promoter in canola. transformation of cotyledonary petioles was achieved via agrobacterium tumefaciens. the insertion of transgene was verified by pcr and dna dot blotting. rt-pcr analysis indicated that the transgenic canola was able to express ...

background and aims: candida albicans is the most common cause of vulvovaginitis candidiasis that is the most common vaginitis in human. it is estimated that more than 90% of these infections are caused by candida albicans. medical treatment for these infections is carried out with chemotherapeutic drugs such as azoles. the increasing resistance of c. albicans to the azoles as well as their pro...

in this study, nystatin liposomal formulation was prepared and characterized. the physicochemical properties of formulations including vesicle size, drug entrapment stability and in vitro release were studied. the highest entrapment efficiency of nystatin into liposomes was obtained about 70% when cholesterol (cho) was added to the formulations prepared with dipalmitoylphosphatidylcholine. in a...