objective: the present study was undertaken to evaluate anti-depressant activity of myristica fragrans(ms). materials and methods: male wistar rats were subjected to imipramine and herbal extract ofms for their antidepressant activity using forced swimming test (fst), reserpine reversal test (rrt), haloperidol-induced catalepsy (hic), and pentobarbitone sleeping time (pst). results: administrat...

introduction: depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. the presently using drugs can impose a variety of side-effects including cardiac toxicity, hypopiesia, sexual dysfunction, body weight gain, and sleep disorder. during the last decade, there is a growing interest in the therapeutic effects of natural products on mental disorders. am...

introduction: celastrus paniculatus seed oil, commonly known as malkangni or jyotishmati, was in use from time immemorial to treat brain related disorders. celastrus paniculatus seed oil has significant antidepressant-like activity in chronic unpredictable stressed mice. the present study was undertaken to evaluate the antidepressant-like effect of celastrus paniculatus seed oil in unstressed m...

objective: pimpinella anisum (p. anisum) has different pharmacological properties such as anticonvulsant, analgesic, tranquilizer, antidepressant and anti-anxiety effects. in this study the antidepressant-like effect of aqueous and ethanolic extracts of p. anisum fruit in mice was investigated. materials and methods: forced swimming test (fst) and tail suspension test (tst) were used to determi...

objective(s) this study planned to assess antidepressant like activity of aqueous extract from leaves of citrus maxima merr. (rutaceae). materials and methods boiling was used for aqueous extraction. acute toxicity study was performed in mice. antidepressant activity was studied using locomotor activity test, modified forced swimming test (fst) and tail suspension test (tst). three doses 100, 2...

Methanol extract of dried leaves of Momordica charantia Linn ( Cucurbitaceae ) was investigated for anxiolytic, antidepressant and anti-inflammatory activities in animal models. Anxiolytic activity of methanol extract of dried leaves of Momordica charantia Linn was tested by elevated plus maze test and the results showed a significant anxiolytic effect comparable, with diazepam in all the t...

Antidepressant activity of crocin, saffron main component, has been established before. Based on previous study, it is suggested that elevation in the levels of BDNF (brain-derived neurotrophic factor), CREB (cAMP response element binding) and VGF neuropeptide could be considered as one probable molecular mechanisms involved in antidepressant activity of long term crocin administration in the r...

methanol extract of dried leaves of momordica charantia linn ( cucurbitaceae ) was investigated for anxiolytic, antidepressant and anti-inflammatory activities in animal models. anxiolytic activity of methanol extract of dried leaves of momordica charantia linn was tested by elevated plus maze test and the results showed a significant anxiolytic effect comparable, with diazepam in all the teste...

Objective(s) This study planned to assess antidepressant like activity of aqueous extract from leaves of Citrus maxima Merr. (Rutaceae). Materials and Methods Boiling was used for aqueous extraction. Acute toxicity study was performed in mice. Antidepressant activity was studied using locomotor activity test, modified forced swimming test (FST) and tail suspension test (TST). Three doses 100...

Objective: The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans(MS). Materials and Methods: Male Wistar rats were subjected to imipramine and herbal extract ofMS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST). Results: Administr...