background: the use of thrombolytic agents in the treatment of hemodynamically stable patients with acute submassive pulmonary embolism (pte) remains controversial. we, therefore, conducted this study to compare the effect of thrombolytic plus anticoagulation versus anticoagulation alone on early death and adverse outcome following submassive pte. methods: w e conducted a study of patients with...

conclusions the determination of warfarin dose, based on genotyping, might reduce the time to achieve stable anticoagulation of warfarin dose and length of hospital stay. patients and methods in this prospective cohort study, 200 pediatric patients, who required warfarin therapy after cardiac surgery, were enrolled and divided into two groups. for 50 cases, warfarin was prescribed based on thei...

background: pregnant patients with mechanical heart valves require anticoagulation. the risk of bleeding and embryopathy associated with oral anticoagulants must be weighed against the risk of valve thrombosis. methods: in this prospective study, undertaken between 1999 and 2009, 53 pregnancies (47 women with mechanical mitral valves; 29.8 ± 4.8 years old) were studied. patients were divided in...

introduction cerebral haemorrhage could complicate post operative course after cardiac surgery, especially after multiple mechanical valves replacement needing for anticoagulation. the interruption of vitamin k antagonists in this cases, to avoid the enhancement of the cerebral haemorrhage, can be performed with reasonable safety. case presentation we report the case of a patient who underwent ...

Anticoagulants are effective in the prevention and treatment of a variety of arterial and venous thrombotic disorders but are associated with an increased risk of serious bleeding complications. Based on well documented studies of patients using vitamin K antagonists the incidence of major bleeding is 0.5%/year and the incidence of intracranial bleeding is 0.2%/year, however, in real life pract...

New oral anticoagulants: a practical guide on prescription, laboratory. The prescription of new oral anticoagulants NOAC. Label2012202155s000lbl.pdf.Oral anticoagulants OACs are used for the prevention of embolus in atrial. Www.sspcrs.ielibrhtmlOralAnticoagulantIndividualReimbursemenApplication.pdf.oral anticoagulants Baglin Rose, 1998 Baglin et al, 2006. Anticoagulation control but results in ...

Anticoagulants are amongst the most commonly prescribed medications worldwide. Although rare, localised and systemic drug reactions have been reported with anticoagulants that can lead to significant morbidity and mortality. Some of the first signs of drug reactions to anticoagulants are cutaneous changes that, when recognised early, can prevent significant complications. Dermatologists should ...

Anticoagulants are widely used in patients with pulmonary arterial hypertension (PAH) to prolong survival. However, there is a lack of robust evidence demonstrating the benefits of anticoagulants in PAH patients and very little is known about the complications of their use in this population. The objective of this study is to compare the safety of routine administration of oral anticoagulants b...