The use of the oxime P2S as intravenous therapy for organophosphorus anticholinesterase poisoning is well known. In emergency situations this route of administration may prove impractical due to severe symptoms of anticholinesterase poisoning and therefore the intramuscular route is to be preferred. The absolute intramuscular dose of P2S per man, recommended as necessary for adequate therapy of...

Donepezil is a piperidine based agent that is used for treatment of Alzheimer’s disases. This agent act as acetylcholine esterase inhibitor and therefore, synthesis of piperidine compounds to evaluate anticholinesterase activity is very popular field in medicinal chemistry [1]. Thus, in this study some novel piperidine derivatives were synthesized in order to observe their probable anticholines...

BACKGROUND Ethnomedicinally Rumex hastatus D. Don has been used since long for various ailments especially in neurological disorders. The reported data and the importance of Rumex genus demonstrate the vital medicinal value of R. hastatus. METHODS In the current investigational study, isolation of essential oil and its antioxidant and anticholinesterase assays were performed. The essential oi...

Citation: Ibrar A, Khan A, Ali M, Sarwar R, Mehsud S, Farooq U, Halimi SMA, Khan I and Al-Harrasi A (2018) Combined in Vitro and in Silico Studies for the Anticholinesterase Activity and Pharmacokinetics of Coumarinyl Thiazoles and Oxadiazoles. Front. Chem. 6:61. doi: 10.3389/fchem.2018.00061 Combined in Vitro and in Silico Studies for the Anticholinesterase Activity and Pharmacokinetics of Cou...

The anticholinesterase agents, physostigmine, neostigmine, and diisopropylfluorophosphonate were studied for their effect on the vasoconstrictor responses of perfused mesenteric arteries of rat produced by stimulation of their sympathetic postganglionic nerves. The experiments were performed at 30°C. All three anticholinesterase drugs greatly potentiated the vasoconstrictor response to nerve st...

Purpose of the Study: Textured soy protein (TSP) and Ajil are two processed forms of soybean (Glycine max L.) which are widely consumed by Iranian for nutritional purpose. Recently, we have reported antioxidant and anticholinesterse effect of raw soybean (RS) which has been attributed to isoflavones such as genistein. In this work, we aimed to compare in vitro antioxidant and antichoinesterase ...

Congenital or hereditary myasthenia describes a heterogeneous group of disorders in which the immune system is not implicated. Treatment has previously depended on anticholinesterase medication. The effectiveness of 3,4-diaminopyridine (3,4-DAP), a preparation that enhances acetylcholine release from motor nerve terminals, has been evaluated using a series of standardised strength measures. Six...

the present study investigates the antioxidant, anticancer, anticholinesterase, anti-genotoxic activities and phenolic contents of flower, fruit and seed methanol extracts of hypericum retusum aucher. the amounts of protocatechuic acid, catechin, caffeic acid and syringic acid in methanol extracts were determined by hplc. total phenolic content of h. retusum seed extract was found more than fru...