Tuberculosis and smoking are among the most pressing issues in modern health care system world. patients who smoke confirmed to have reduced effectiveness of anti-tuberculosis therapy, unsatisfactory prognosis a specific disease, higher risk treatment failure mortality from this disease. Diseases such as HIV alcoholism increase ineffective tobacco smokers. In addition, leads increased virulence...

Diabetic foot ulcers are recognized to be a severe complication of diabetes, increasing the risk amputation and death. The bacterial infection with virulent resistant bacteria as Proteus mirabilis greatly worsens wound may not treated conventional therapeutics. Developing new approaches target virulence can helpful conquer such infections. In current work, we evaluated anti-virulence activities...

background chlorhexidine gluconate (chx) is the most common antimicrobial agent used against oral pathogens, however information on its ability to inhibit and disrupt anaerobic single and multispecies biofilms is relatively unknown. objectives the purpose of this study was to test the efficacy of chx for its biofilm inhibition and disruption properties using crystal violet assay. materials and ...

Objective: Considering the emergence of biofilm-associated pathogens with multidrug resistance, the objective(s) of the present study was to evaluate the anti-virulence property of Syzygium aromaticum extracts/fractions against 2 multidrug-resistant catheter isolates. Materials and Methods: Pulverized clove buds were subjected to bioactivity-guided isolation to identify the bioactive extract/fr...

The superantigenic staphylococcal enterotoxins are important virulence factors and contribute to various diseases, including food poisoning and toxic shock. Dexamethasone, an anti-inflammatory agent, attenuated staphylococcal enterotoxin B (SEB)-induced hypothermia and serum proinflammatory cytokines and improved survival from 0% to 86% in a lethal mouse model of SEB-mediated shock.

  In the present study, the effect of the high and low virulence S. iniae strains on oxidative activity and cytotoxic effects of trout spleen macrophages were studied. Spleen macrophages were collected from trout. Luminol was used as chemiluminigenic probe. Phorbolmyristate acetate (PMA) also was used as positive control activating agent of respiratory burst and significantly stimulated pr...

The increase in multidrug-resistant pathogens has created new anti-pathogenic and anti-virulence compounds. This is because of the behavioural changes bacteria acquire, such as increased antibiotic resistance virulence capacity. social behaviour maintained through a signalling transduction pathway called Quorum sensing. present study aims to evaluate inhibition quorum sensing Bacillus subtilis ...