lisinopril dihydrate (angiotensin converting enzyme inhibitor) is a lysine derivative of enalaprilat and does not require hydrolysis to exert pharmacological activity. it has an extensive hepatic first pass metabolism resulting in a bioavailabil-ity of 6-60%. to overcome the poor bioavailability of the drug, transdermal patches have been prepared. the present study also aims at optimization of ...

the purpose of this research was to formulate and systemically evaluate in-vitro and in-vivo performances of mucoadhesive propranolol hydrochloride microspheres for its potential use in the treatment of hypertension, myocardial infraction and cardiac arrhythmias. propranolol hydrochloride mucoadhesive microspheres, containing carbopol-934p as mucoadhesive polymer and ethyl cellulose as carrier ...

cosmos caudatus is widely used as a traditional medicine in southeast asia. c. caudatus has been reported as a rich source of bioactive  compounds such as ascorbic acid, quercetin, and chlorogenic acid. studies have shown that c. caudatus exhibits high antioxidant capacity and various medicinal properties, including anti-diabetic activity, anti-hypertensive properties, anti-infl ammatory respon...

purpose : to investigate the association of primary open angle glaucoma (poag) and systemic hypertension in patients referred to farabi eye hospital methods : in this case-control study in farabi eye hospital. one hundred patients were selected randomly from poag patients of glaucoma clinic, farabi eye hospital. control group consists of 100 patients, candidates for cataract surgery. history of...

Background: Leptadenia hastata (L. Hastata) is a plant used for various diseases in Nigeria. This study evaluated the protective effects of L. hastate on the haematological and biochemical alterations in adrenaline-induced hypertensive rats. Methods: Twenty-five rats were divided equally into five groups (A-E). Groups A-D were given 0.5 mg/kg adrenaline, groups A and B were treated with 100 an...

BACKGROUND Hemorrhage volume is an important predictor of outcome in patients with intracerebral hemorrhage (ICH). It is not clear why in some patients ICH volume is larger than in others. Identification of modifiable factors responsible for large-volume hemorrhage in hypertensive patients may help to reduce ICH-related morbidity and mortality. OBJECTIVE The objective of this study was to ide...

background chlorhexidine gluconate (chx) is the most common antimicrobial agent used against oral pathogens, however information on its ability to inhibit and disrupt anaerobic single and multispecies biofilms is relatively unknown. objectives the purpose of this study was to test the efficacy of chx for its biofilm inhibition and disruption properties using crystal violet assay. materials and ...