the crude methanolic extract of the seeds of celastrus paniculatus along with its organic soluble fractions were tested for their possible antioxidant and anti-alzheirmer (ad) activity. the extracts showed prominent dpph free radical scavenging activity, inhibiting activity of authentic peroxynitrite (onoo-) and inhibition of total reactive oxygen species (ros) generation. in dpph radical scave...

Background: Thymus persicus is one of the Iranian endemic medicinal plants, that its decoction and various products have plenty of food and pharmaceutical uses. Objective: Evaluation of T. persicus products metabolite contains and determination of the best antioxidant, anti-diabetic and anti-Alzheimer extract. Methods: Samples total phenolic, flavonoid and tannin contents were determined by F...

objective(s):alzheimer's disease (ad) is the most common age-related neurodegenerative disorder. one of the hallmarks of ad is an abnormal accumulation of fibril forms of tau protein which is known as a microtubule associated protein. in this regard, inhibition of tau aggregation has been documented to be a potent therapeutic approach in ad and tauopathies. unfortunately, the available syn...

background: alzheimer’s disease (ad) is one of the most important neurodegenerative disorder. anti‑cyclic citrullinated peptide (anti‑ccp) may all be involved in the development of vascular disease such as ad. the aim of this study is detection of seropositivity for anti‑ccp antibody in ad patients. methods: in our study, 30 patients with ad and 29 healthy controls (age and‑sex matched) were re...

alzheimer's disease (ad) is a chronic neurodegenerative disease that accounts for 60 to 80 percent of all dementia cases. the exact cause of alzheimer`s disease is still unknown, but recent studies suggest neuro-inflammation as an important part of the pathogenesis of the disease. this brings in mind using non-steroidal anti-inflammatory drugs (nsaid) as treatment or prevention of the dise...

BACKGROUND There has been no analysis of brain tissue from longitudinally observed, cognitively tested patients to validate whether anti-inflammatory medications protect against the pathological changes of Alzheimer disease. OBJECTIVE To investigate the role of anti-inflammatory medications in alleviating the pathological features of Alzheimer disease. DESIGN AND MAIN OUTCOME MEASURES A 5-y...

Alzheimer's disease (AD) is a chronic neurodegenerative disease that accounts for 60 to 80 percent of all dementia cases. The exact cause of Alzheimer`s disease is still unknown, but recent studies suggest neuro-inflammation as an important part of the pathogenesis of the disease. This brings in mind using non-steroidal anti-inflammatory drugs (NSAID) as treatment or prevention of the disease. ...

Demansın en yaygın şekli olan Alzheimer hastalığı, hafıza kaybı ve diğer bilişsel problemler ile karakterize karmaşık bir hastalıktır. Artan prevalansa sahip hastalığının fizyopatolojisinin anlaşılması bu hastalığın tedavisinde etkin bileşiklerin yapılarının araştırılması, yeni ilaç moleküllerinin geliştirilmesine yardımcı olacaktır. Bu anlamda hastalık üzerinde etkili hipotezlerin, yapısının e...

This scientific commentary refers to “Key questions for the evaluation of anti-amyloid immunotherapies Alzheimer”s disease', by Liu et al. (https://doi.org/10.1093/braincomms/fcad175)