objective: to compare immunogenicity of a recombinant hepatitis b (hb) vaccine in two groups of neonates born in two cities of iran with different geographic and ethnic backgrounds.   materials and methods: ten micrograms of a recombinant hb vaccine was administered under field condition to iranian healthy neonates at 0, 1.5 and 9 months intervals. the subjects consisted of two groups of 290 an...

We have previously demonstrated that the murine humoral immune responses to the group-specific a and subtype-specific d/y determinants of hepatitis B surface antigen (HBsAg) are controlled by H-2-linked immune response (Ir) genes. High responder (H-2d,q), intermediate responder (H-2a greater than b greater than k) and nonresponder (H-2f,s) haplotypes have been identified (8, 9). The kinetics an...

introduction: vaccination with the major surface antigen of hepatitis b virus (hbsag) induces anti-hbs antibody production and level of 10 iu/l is considered protective. it has been shown that the level of anti-hbs antibody does wane after vaccination. the aim of this study was to evaluate the persistence of anti-hbs antibodies in healthy iranian children 10 years after primary vaccination. met...

Platelet aggregation indicating antigen-antibody complex formation was observed when hepatitis B surface (HBs) antigen and antibody were mixed. Platelet aggregation titers were determined for serum specimens found positive by radioimmunoassay for either HBs antigen or HBs antibody. From these determinations, incidence of HBs antigen-antibody complexes was found to be higher in HBs antigen seraa...

Background: Hepatitis B is an important infectious disease.  Since several years ago, mass vaccination against this viral infection has become as part of routine vaccination schedule of Iran.  However, some healthy neonates, children and adults fail to generate a protective antibody response after vaccination.Objectives: To investigate distribution of HLA class-I and class-II antigens in health...

To evaluate the relationships between human T lymphotropic virus type I (HTLV-I) and hepatitis virus type B (HBV) infections, we compared both individual and geographical distributions of carriers of HTLV-I and HBV, and antibody positives to HBV in two ATL-endemic islands in Kyushu, Japan. The positive rates of antibodies to HTLV-I (anti-HTLV-I-Ab) in sera among healthy inhabitants older than 3...

abstract background thalassemia patients that are conventionally treated by a regular transfusion regimen are exposed to blood born viral infections.the aim of this study was to investigate the seroprevalence of hepatitis b virus (hbv), hepatitis c virus (hcv) , and human immunodeficiency virus(hiv) among all multitransfused thalassemia patients in west north of iran. material and methods a ret...

BACKGROUND Hepatitis B virus (HBV) infection is still reported from adult hemodialysis units. OBJECTIVES To determine the prevalence of anti-HBs antibody in hemodialysis patients and the correlation between levels of anti-HBs antibody with other factors. PATIENTS AND METHODS HBsAg, anti-HBs and anti-HBc antibodies level in 119 hemodialysis patients were evaluated by enzyme-linked immunosorb...

background: hepatitis b is an important infectious disease.  since several years ago, mass vaccination against this viral infection has become as part of routine vaccination schedule of iran.  however, some healthy neonates, children and adults fail to generate a protective antibody response after vaccination. objectives: to investigate distribution of hla class-i and class-ii antigens in healt...