statement of problem: the guided bone regeneration (gbr) technique does not always produce consistent results. bone filling within the space provided by the membrane can be incomplete. purpose: the aim of this study was to evaluate the effect of a collagen membrane (bio-gide) in combination with or without deproteinezed bovine bone mineral (bio-oss) on the healing of calvarial defects in rabbit...

introduction: full crown preparation may have adverse effects on pulp tissue. in this study, the effect of full-crown preparation on intact versus inflamed pulp tissue was studied. methods: fifteen healthy mature cats were randomly selected for this study. the study was performed on four canine teeth of each cat. cats were anesthetized and then radiographs were taken from the canine teeth. clas...

Human beings with diminished decision-making capacities are usually thought to require greater protections from the potential harms of research than fully autonomous persons. Animal subjects of research receive lesser protections than any human beings regardless of decision-making capacity. Paradoxically, however, it is precisely animals' lack of some characteristic human capacities that is com...

the objective of this study was to evaluate the effect of accell connexus(®) on the quality and rate of healing in experimental defects of rabbit calvarium compared to bio-oss®.twelve 2.5-3.5 kg weighing new zealand white rabbits were used. three defects (3×6 mm) were created in the cranium of the animals subsequently filled with accell connexus(®), bio-oss® or served as controls. the animals w...

Experimental research proceeds by hypotheses formulated on the basis of previous or new knowledge and then tested. If they are accepted, they serve as the basis for further hypotheses, and if they are rejected new hypotheses can be developed. In other words, when we are at the frontiers of knowledge the path is forged by "trial and error". When a trial shows a hypothesis is wrong, this is a ste...

Before starting a new animal experiment, thorough analysis of previously performed experiments is essential from a scientific as well as from an ethical point of view. The method that is most suitable to carry out such a thorough analysis of the literature is a systematic review (SR). An essential first step in an SR is to search and find all potentially relevant studies. It is important to inc...

Background and purpose: Research studies indicate that almost 80% of the present day drugs are derived directly or indirectly from medicinal plants. The estimation of a safe starting dose is a concern when a new substance is to be investigated including medicinal plants, in clinical and laboratory studies. This study was intended to explore a simple and reliable method of calcu...

Introduction: Full crown preparation may have adverse effects on pulp tissue. In this study, the effect of full-crown preparation on intact versus inflamed pulp tissue was studied. Methods: Fifteen healthy mature cats were randomly selected for this study. The study was performed on four canine teeth of each cat. Cats were anesthetized and then radiographs were taken from the canine teeth. Clas...