conclusions the present data do not suggest that pregabalin is more efficacious than placebo in the treatment of lumbar and cervical radicular pain. however, the small sample size of this study may have affected the ability to detect such a difference. results data on 19 of the 39 patients recruited were available for analysis. no statistically significant differences in the pain, disability, a...

Intensive research on the neurobiology of pain over the past two decades has revealed many receptors, ion channels and enzymes with potential as novel targets for development of a new generation of analgesic agents. However, despite large investment in preclinical and clinical development of small molecules and biologics as potential novel pain therapeutics, very few have reached the clinic. He...

BACKGROUND AND OBJECTIVES Pain treatment involves the usage of common and opioid analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs) and adjuvant analgesics. Traditionally, these drugs are administered systemically or into the neuraxis. However, when analgesics are applied through these pathways, they are associated with significant side effects, which can hinder its use. Topical administ...