the uses of non-steroidal anti-inflammatory drugs (nsaids) are limited by a variety of side effects. so research on preparing new analgesic agents is important. according to some reports about the analgesic activity of hydrazide and hydrazine derivatives a new series of these compounds were synthesized in order to obtain new analgesic compounds. the final compounds 10a-10e and 15a-15d were prep...

objective(s):cone snails are estimated to consist of up to 700 species. the venom of these snails has yielded a rich source of novel peptides. this study was aimed to study the analgesic effect of persian gulf conus textile and its comparison with morphine in mouse model. materials and methods: samples were collected in larak island. the venom ducts were isolated and kept on ice then homogenize...

methanolic extract of solanum trilobatum linn. (mest) belonging to the family of solanacea was evaluated by hot plate and acetic acid induced writhing methods to assess its analgesic activity. the extract was also evaluated for its anti-inflammatory activity by subjecting into carrageenan, and cotton pellet induced granuloma tests for its effect on acute and chronic phase inflammation models in...

various extracts of sarcostemma viminale were screened for central analgesic activity by hot plate test, peripheral analgesic activity by acetic acid-induced writhings, cns depressant activity by pentobarbitone-induced sleep and locomotor activity testing methods and anthelmintic activity on the earthworms pheretima posthuma . results showed that petroleum ether and ethyl acetate extracts had g...

leptadenia reticulata was reported to be used for several medicinal purposes. the present study was undertaken to evaluate anti-inflammatory, analgesic and lipid peroxidation inhibition activities of l. reticulata. the anti-inflammatory assay was performed by λ-carrageenan and formalin induced paw edema test. pro inflammatory mediators (il2, il6, tnf-α) in serum of treated and control organism ...

objective: the present study was undertaken to evaluate the possible analgesic, neuropharmacological, anti-diarrheal, and cytotoxic activities of the ethanol extract of leaves of solanum sisymbriifolium lam. (family: solanaceae). materials and methods: the analgesic activity was measured by acetic acid-induced writhing inhibition test. the neuropharmacological activities were evaluated using ho...

Various extracts of Sarcostemma viminale were screened for central analgesic activity by hot plate test, peripheral analgesic activity by acetic acid-induced writhings, CNS depressant activity by pentobarbitone-induced sleep and locomotor activity testing methods and anthelmintic activity on the earthworms Pheretima posthuma . Results showed that petroleum ether and ethyl acetate extracts h...

A series of 2-methylthio-1,4-dihydropyrimidine derivatives (II) were synthesized in good yields by alkylation of 1,2,3,4-tetrahydropyrimidines (I) with methyl iodide in the presence of pyridine. Their structures were confirmed by elemental analysis, IR and 1H NMR spectra. The compounds were tested for analgesic activity by acetic acid induced writhing method. Compounds IIh, IIe, IIk and IIl sho...

present study reports analgesic activity of petroleum ether, chloroform, ethyl acetate and methanolic extracts of leaves and seeds of trigonella foenum-graecum linn. (fabaceae) using hot plate method for evaluation of central analgesic activity and acetic acid induced writhing test for evaluation of peripheral analgesic activity in mice.   all the extracts of trigonella foenum-graecum showed si...

A series of 2-methylthio-1,4-dihydropyrimidine derivatives (II) were synthesized in good yields by alkylation of 1,2,3,4-tetrahydropyrimidines (I) with methyl iodide in the presence of pyridine. Their structures were confirmed by elemental analysis, IR and 1H NMR spectra. The compounds were tested for analgesic activity by acetic acid induced writhing method. Compounds IIh, IIe, IIk and IIl sho...