Defects in cell cycle control and increased genomic instability, including gene amplification, often occur during cancer development. Cyclin Dl plays a pivotal role in G1, and this gene is frequently amplified and overexpressed in several types of human cancer. This study demonstrates that ectopic overexpression of cyclin Dl in a rat liver epithelial cell line markedly increased the yield of ce...

We estimated the speed of Zika virus introduction in Brazil by using confirmed cases at the municipal level. Our models indicate a southward pattern of introduction starting from the northeastern coast and a pattern of movement toward the western border with an average speed of spread of 42 km/day or 15,367 km/year.

Dengue is a public health problem in the tropics and subtropics. There are several vaccine candidates in clinical development. However, there may be gaps in the new vaccine introduction after vaccine licensure before it becomes available in developing countries. In anticipation of the first dengue vaccine candidate to be licensed, Dengue Vaccine Initiative (DVI) and, its predecessor, Pediatric ...

I.1. Physical motivation. From [St]: consider a function T (x) as representing the value of a physical variable at a particular point x in space. Is this a realistic thing to do? What can you measure? Suppose T (x) represents temperature at a point x in a room. You can measure the temperature with a thermometer, placing the bulb at the point x. Unlike the point, the bulb has nonzero size, so wh...

Publication has become a burning issue among Indian medical fraternity owing to certain academic and professional necessities. The large number of submissions to the anaesthesia journals has resulted in accumulation of too much below average scientific material. A properly written manuscript is the dream of every editor and reviewer. The art of preparing a manuscript can be acquired only by fol...

P aul Samuelson (1969) was once asked by a physicist for a law in economics that was both nontrivial and true. This is a difficult challenge, as many (roughly) true results are in the end rather trivial (for example, demand curves slope down), while many nontrivial results in economics in fact require too much sophistication and rationality on the part of the agents to actually hold true in pra...