In the Drosophila peripheral nervous system, proneural genes direct the formation of different types of sensory organs. Here, we show that amos is a novel proneural gene that promotes multiple dendritic (MD) neuron formation. amos encodes a basic-helix-loop-helix (bHLH) protein of the Atonal family. During embryonic development, amos is expressed in patches of ectodermal cells, and the expressi...

Anti-microRNA (miRNA) oligonucleotides (AMOs) with 2'-O-Methyl (2'OMe) residues are commonly used to study miRNA function and can achieve high potency, with low cytotoxicity. Not withstanding this, we demonstrate the sequence-dependent capacity of 2'OMe AMOs to inhibit Toll-like receptor (TLR) 7 and 8 sensing of immunostimulatory RNA, independent of their miRNA-targeting function. Through a scr...

BACKGROUNDS To investigate the inhibiting effects of multi-target anti-microRNA antisense oligonucleotide (MTg-AMOs) on proliferation and migration of human gastric cancer cells. METHODS Single anti-microRNA antisense oligonucleotides (AMOs) and MTg-AMOs for miR-221, 21, and 106a were designed and transfected into SGC7901, a gastric cancer cell line, to target the activity of these miRNAs. Th...

fails to resolve, demonstrating that, as with the selection of other neural precursors, the resolution of amos expression involves lateral inhibition. In the antennal imagi-nal disc, amos mRNA is detected in three semicircular The peripheral nervous system (PNS) is made up of an bands that correspond to the sites where olfactory sen-array of different sensory structures that detect aspects sill...

In this paper we present AmOS, the Ambient Object System that underlies the Ambience programming language. AmOS implements a computation model that supports highly dynamic behaviour adaptation to changing contexts. Apart from being purely object-based, AmOS features first-class closures, multimethods and contexts. Dynamic method scoping through a subjective dispatch mechanism is at the heart of...

Present databases, whether on centralized or parallel DBMSs, do not deal well with scalability. We present an architecture for Wintel multicomputers termed AMOS-SDDS, coupling a high-performance main-memory DBMS AMOS-II and a manager of Scalable Distributed Data Structures SDDS-2000. SDDS-2000 provides the scalable data partitioning in distributed RAM, supporting parallel scans with function sh...

AMOS (Active Mediators Object System) is an architecture to model, locate, search, combine, update, and monitor data in information systems with many work stations connected using fast communication networks. The approach is called active mediators, since it introduces an intermediate level of ‘mediator’ software between data sources and their use in applications and by users, and since it supp...

This working document gives an overview of some research projects whose aims are similar to the Amos II project. Amos II is related to research in the areas of OO views, data integration, distributed databases and general query processing. We have surveyed the literature on a number of multi-database integration and OO view projects and compared their approaches to Amos II . 1 Multi-database in...

Proneural genes encode basic-helix-loop-helix (bHLH) transcription factors required for neural precursor specification. Recently amos was identified as a new candidate Drosophila proneural gene related to atonal. Having isolated the first specific amos loss-of-function mutations, we show definitively that amos is required to specify the precursors of two classes of olfactory sensilla. Unlike ot...