background: the seladin-1 (selective alzheimer disease indicator-1), also known as dhcr24, is a gene found to be down-regulated in brain region affected by alzheimer disease (ad). whereas, hair follicle stem cells (hfsc), which are affected in with neurogenic potential, it might to hypothesize that this multipotent cell compartment is the predominant source of seladin-1. our aim was to evaluate...

introduction: olibanum improves memory in different models of learning. however, the effect of olibanum on models of alzheimer’s disease has been less studied. in the present study, the effect of olibanum on memory in normal rats and in a rat model of alzheimer disease induced by intracerebroventricular injections of streptozotocin was evaluated. methods: rats received an aqueous extract of oli...

abstract alzheimer’s disease (ad) is the most common cause of dementia in elderly people. the prevalence of alzheimer diseases is increasing in the world due to population aging. metabolic disease such as diabetes and obesity play important role in alzheimer disease. hyperglycemia can play important role in brain damage. it causes cognitive impairments, functional and structural alterations in ...

alzheimer disease is one form of dementia in old age. alzheimer disease, the incurable disease, which is usually in the seventh decade of human life, shows its symptoms. the disease may be present for years without clinical symptoms. the current study identified the genes with altered expression in patients with alzheimer disease. the important sequence of each gene in alzheimer disease was fou...

background: alzheimer’s disease (ad) is the most common type of dementia. demonstrating the modifiable risk factors of ad can help to plan for prevention of this disease. the aim of the current review was to characterize modifiable cardiovascular risk factors of ad using existing data and determine their contribution in ad development in iran and the world. methods: the systematic search was do...

alzheimer is age-related, progressive brain degeneration disease. it destroys memory slowly. the number of people living with ad is increasing as fast as the count of aged population and extension of bad nutrition habits. the main cause of ad is not clearly known, but prior studies noted the importance of inflammation in tau hyperphosphorylation and failure of microglia to clear ab peptide accu...

conclusions according to iranian traditional medicine, the brain dystemperement is considered the main causes of alzheimer disease. by correcting the brain dystemperement, alzheimer can be well managed. this study helps to suggest a better strategy for preventing and treating alzheimer in the future. results findings showed that alzheimer disease has the most overlap with nesyan (fisad-e-zekr, ...

reactive oxygen species (ros) are produced in many normal and abnormal processes in humans, including atheroma, asthma, joint diseases, cancer, and aging. basal levels of ros production  in  cells  could  be  related  to  several  physiological functions  including  cell proliferation, apoptosis and homeostasis. however, excessive ros production above basal levels would impair and oxidize dna, ...

the etiopathogenesis of dementia in alzheimer's disease (ad) is still unclear. however, long-term oxidative stress is believed to be one of the major contributing factors in progression of neuronal degeneration and decline of cognitive function in ad. in order to assess the presence of oxidative stress in ad, we examined the enzymatic activities of the erythrocyte cu-zn superoxide dismutase (cu...

background: alzheimer's disease as a neurodegenerative disorder is the commonest type of dementia. a growing number of genes have been reported as the risk factors, which increase the susceptibility to alzheimer's disease. apolipoprotein e ( apoe) , which its ε4 allele has been reported as a risk factor in late onset alzheimer's disease (ad), is the main cholesterol carrier in the brain. the ma...