نتایج جستجو برای: Alternative Splicing

تعداد نتایج: 321104  

Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...

Journal: :iranian biomedical journal 0
آرمین عطار armin attar محسن خسروری مهارلویی mohsen khosravi maharlooi سارا خوشخو sara khoshkhou احمد حسینی ahmad hosseini منصوره جابری پور mansoureh jaberipour آرمان دهقان arman dehghan احمد منبتی

introduction: endothelial progenitor colony forming unit-endothelial cells (cfu-ec) were first believed to be the progenitors of endothelial cells, named endothelial progenitor cells. further studies revealed that they are monocytes regulating vasculogenesis. the main hindrance of these cells for therapeutic purposes is their low frequency and limited replicative potentials. this study was unde...

Journal: :iranian journal of parasitology 0
xiaoqiang wang college of chemistry and bioengineering, lanzhou jiaotong university, lanzhou, p.r. china juntao ding college of chemistry and bioengineering, lanzhou jiaotong university, lanzhou, p.r. china xiaola guo state key laboratory of veterinary etiological biology, key laboratory of veterinary parasitology of gansu province, lanzhou veterinary research institute, caas, lanzhou, gansu, china yadong zheng state key laboratory of veterinary etiological biology, key laboratory of veterinary parasitology of gansu province, lanzhou veterinary research institute, caas, lanzhou, gansu, china

background: echinococcus multilocularis is a tiny tapeworm, responsible for 0.3~0.5 million alveolar echinococcosis in humans. methods: we searched relevant papers published between 1981 and 2013 based on the database sources such as pubmed and google scholar, and collected and integrated the data for analysis. results: the parasite is able to use host-originated molecules to modulate its devel...

Journal: :gene, cell and tissue 0
susana ferreira department of genetics, faculty of medicine, university of porto, oporto, portugal; department of genetics, faculty of medicine, university of porto, 4200319, porto, portugal. tel: +351-225513647, fax: +351-225513648 miguel viana-baptista department of neurology, egas moniz hospital, lisbon, portugal daniel rodrigues institute for molecular and cell biology, oporto, portugal joao paulo oliveira department of genetics, faculty of medicine, university of porto, oporto, portugal; medical genetics outpatient clinic, sao joao hospital centre, oporto, portugal; nephrology research and development group, university of porto, oporto, portugal

results approximately 20% of the patients expressed alternatively spliced transcripts of gla mrna involving exon 3. we additionally report that such non-canonical transcripts are physiologically expressed at trace levels in healthy individuals, and that their expression in leukocytes markedly increased in blood samples kept at room-temperature for 48 hours before rna extraction. background defi...

Journal: :iranian journal of basic medical sciences 0
shima rahmati department of genetics, faculty of basic sciences, shahrekord university, shahrekord, iran. child growth and development research center, isfahan university of medical sciences, isfahan, iran § contributed equally to this work modjtaba emadi-baygi department of genetics, faculty of basic sciences, shahrekord university, shahrekord, iran research institute of biotechnology, shahrekord university, shahrekord, iran.child growth and development research center, isfahan university of medical sciences, isfahan, iran § contributed equally to this work parvaneh nikpour 3 pediatric inherited diseases research center 4 department of genetics and molecular biology, faculty of medicine, isfahan university of medical sciences, isfahan, iran 5 child growth and development research center, isfahan university of medical sciences, isfahan, iran § contributed equally to this work elaheh emadi-andani child growth and development research center, isfahan university of medical sciences, isfahan, iran § contributed equally to this work

objective(s):previous studies demonstrate that changes in pre-mrna splicing play a significant role in human disease development. furthermore, many cancer-associated genes are regulated by alternative splicing. there are mounting evidences that splice variants which express predominantly in tumors, have clear diagnostic value and may provide potential drug targets. located on the x chromosome, ...

Journal: :avicenna journal of medical biotechnology 0

vascular endothelial growth factor (vegf-a) is one of the most important regulatory factors in pathological and physiological angiogenesis. alternative splicing is a complicated molecular process in vegf-a gene expression which adds complexity to vegf-a biology. among all vegf-a exons, alternative splicing of exon 8 is the key determinant of isoform switching from pro-angiogenic vegf-xxx to ant...

Journal: :international journal of molecular and cellular medicine 0
mohsen khosravi-maharlooei student research committee, cell and molecular medicine research group, shiraz university of medical sciences, shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences) mansooreh jaberipour shiraz institute for cancer research, shiraz university of medical sciences, shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences) ahmad hosseini tashnizi shiraz institute for cancer research, shiraz university of medical sciences, shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences) armin attar student research committee, cell and molecular medicine research group, shiraz university of medical sciences, shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences) fatemeh amirmoezi student research committee, cell and molecular medicine research group, shiraz university of medical sciences, shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences) mojtaba habibagahi immunotherapy laboratory, department of immunology, school of medicine, shiraz university of medical sciences, shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences)

telomerase and systems controlling their activity have been of great attention. there are controversies regarding the role of the alternative splicing forms of the human telomerase reverse transcriptase (htert), the catalytic subunit of telomerase. therefore, the correlation between telomerase enzyme activity, the abundance of alternatively spliced variants of htert and doubling time of a serie...

2016
Nicholas J Kramer Aaron D Gitler

The regeneration of axons relies on a previously unknown mechanism that involves the regulation of alternative splicing by CELF proteins.

2011
Amit Berson Galit Shaltiel Shahar Barbash Yael Goll Geula Hanin Keren Ofek Maya Ketzef Yehudit Gnatek Alon Friedman Hermona Soreq A. Mykowska A. Fiszer M. Wojciechowska W. J. Krzyzosiak Alla Rynditch Liudmyla Tsyba Mykola Dergai Dmytro Morderer Inessa Skrypkina Oleksii Nikolaienko Oleksandr Dergai Sergii Kropyvko

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2012
Lu Chen Jaime M. Tovar-Corona Araxi O. Urrutia

Alternative splicing (AS) is a common posttranscriptional process in eukaryotic organisms, by which multiple distinct functional transcripts are produced from a single gene. The release of the human genome draft revealed a much smaller number of genes than anticipated. Because of its potential role in expanding protein diversity, interest in alternative splicing has been increasing over the las...

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