the relation between microchimerism and allograft tolerance is still a mystery. in this study we determined the presence of peripheral blood microchimerism (pbmc) in female renal transplant recipients from living male donors with second round polymerase chain reaction (pcr). second round pcr was used to find y chromocome products. the degree of pbmc in renal transplant recipinents must be below...

patients and methods this retrospective cohort study included 405 renal transplant patients from kerman university of medical sciences hospital, kerman, iran from 2004 to 2010. kaplan-meier method was used to estimate survival rates of patients, and time-dependent cox regression was used to examine the effect of allograft failure on patient survival. results during 4.06 years (median) of follow...

Background: Despite advances in the medical care of renal transplant recipients which have led to an improvement in allograft survival, renal allograft rejection is still a major ob-stacle to successful organ transplantation. Understanding the mechanisms contributing to allograft rejection will be of great importance for the development of efficient antirejection strategies. Objective: The aim ...

BACKGROUND Allograft survival among black recipients is poorer than among whites. Delayed allograft function is associated with a significant reduction in renal allograft survival. The relationship between delayed allograft function and black race is incompletely specified and was the focus of this investigation. METHODS A non-concurrent study of 325 recipients of cadaveric allografts followe...

Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. Objectives: To eva...

background: regulatory t cells have been suggested to have a protective role against acute rejection in allograft recipients. however, there is little information available about their contribution to chronic rejection process. the role of transforming growth factor-beta 1 (tgf- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. objectives: to eva...

results implementation of modern techniques of immune monitoring, allograft function, awareness about the specific infectious and non-infectious disease in each region improves the quality of renal transplantation. conclusions we need to combine the advance scientific vision with local vigilance to achieve the best outcome in renal allograft recipients evidence acquisitions in this process we s...

background: despite advances in the medical care of renal transplant recipients which have led to an improvement in allograft survival, renal allograft rejection is still a major ob-stacle to successful organ transplantation. understanding the mechanisms contributing to allograft rejection will be of great importance for the development of efficient antirejection strategies. objective: the aim ...

Allograft rejection is a significant cause of renal transplant failure which needs prompt diagnosis and treatment for graft salvage. Angiotensin II type 1 receptor antibody-mediated (AT1R-AMR) increasingly being identified as the etiology in kidney recipients with allograft but without detectable human leukocyte antigen (HLA) antibodies. While some reports have suggested that AT1R-AMR may be re...