In this study the behavioral effects of sectioning the saphenous nerve at the time of application of the loose ligature and the effect of a selective ?1-adrenergic antagonist for two weeks after tying ligatures was examined. Male Sprague-Dawley rats were used in this study. Animals were divided into six groups: Sham-operated, sciatic nerve ligation (CCI), saphenous nerve section (Saph), CCI + S...

In this study the behavioral effects of sectioning the saphenous nerve at the time of application of the loose ligature and the effect of a selective ?1-adrenergic antagonist for two weeks after tying ligatures was examined. Male Sprague-Dawley rats were used in this study. Animals were divided into six groups: Sham-operated, sciatic nerve ligation (CCI), saphenous nerve section (Saph), CCI + S...

introduction: neuropathic pain is one of the common complications of diabetes mellitus which is caused by impairment in nerve conductivity. the role of flavonoid and polyphenol compounds in treatment of neuropathic pain has been revealed, and extract of onion contains significant amounts of these compounds. the aim of this study was to investigate the effect of alcoholic extract of onion on dia...

Abstract Intradermally injected capsaicin induces secondary mechanical hyperalgesia and allodynia outside the primary (i.e., capsaicininjected) site. This secondary mechanical hypersensitivity is attributed to central sensitization in which reactive oxygen species (ROS) play a key role. We examined whether ROS would be differentially involved in secondary mechanical hyperalgesia and allodynia u...

Microglia activation in the spinal cord play a major role pathogenesis of neuropathic pain. The p38 mitogen-activated protein kinase (MAPK) regulates microglia activation. Previously, 2′,3′-dideoxycytidine (ddC), nucleoside reverse transcriptase inhibitor (NRTI), was found to induce mechanical allodynia and cords male female mice. In this study, we investigated MAPK signaling development using ...

Because chronic vincristine (VCR) treatment causes neuropathic pain, as demonstrated by mechanical allodynia, effective therapeutic strategy is required. In this study, we investigated a suppressive effect of imipramine (IMI) on VCR-induced mechanical allodynia in mice. VCR (0.1 mg/kg, intraperitoneally (i.p.)) was administered once per day for 7 d in ICR male mice. Mechanical allodynia was eva...

In the present study, we investigated whether dynamic and static allodynia would be developed in the affected dermatome in murine models of herpetic pain and postherpetic neuralgia and pharmacologically characterized the allodynia. Inoculation with herpes simplex virus type-1 on the femur induced skin lesions in the dermatome including the plantar region of the hind paw from day 5 to day 21 aft...

Most of the anaesthesia related neurological complications are associated with paresthesia upon introduction spinal needle. Steroids may shorten duration effects caused by nerve injury. A 27-year-old female patient undergoing caesarean section experienced during intrathecal After wore off, she developed tactile allodynia. Intravenous hydrocortisone was given; marked improvement pain and allodyn...

introduction: glial activation and secretion of cytokines at the spinal level is known as part of chronic pain pathogenesis. although changes in tnfα at the supraspinal level are reported during chronic pain, its exact role and site of action remain to be elucidated. we investigated the effect of microinfusion of tnfα into the lc in a rat model of neuropathic pain. methods: male wistar rats wer...