نتایج جستجو برای: Allicin

تعداد نتایج: 511  

Journal: :Molecules 2014
Jan Borlinghaus Frank Albrecht Martin C H Gruhlke Ifeanyi D Nwachukwu Alan J Slusarenko

Allicin (diallylthiosulfinate) is a defence molecule from garlic (Allium sativum L.) with a broad range of biological activities. Allicin is produced upon tissue damage from the non-proteinogenic amino acid alliin (S-allylcysteine sulfoxide) in a reaction that is catalyzed by the enzyme alliinase. Current understanding of the allicin biosynthetic pathway will be presented in this review. Being ...

2015
Chen Li Weijian Lun Xinmei Zhao Shan Lei Yandong Guo Jiayi Ma Fachao Zhi

Background. Allicin has anti-inflammatory, antioxidative and proapoptotic properties. Aims. To evaluate the effects and investigate the mechanism of allicin on trinitrobenzenesulfonic acid-induced colitis, specifically with mesalazine or sulfasalazine. Methods. 80 rats were divided equally into 8 groups: control; trinitrobenzenesulfonic acid; allicin prevention; allicin; mesalazine; sulfasalazi...

Journal: :International immunology 2004
Miriam Patya Muayad A Zahalka Alexey Vanichkin Aharon Rabinkov Talia Miron David Mirelman Meir Wilchek Harry M Lander Abraham Novogrodsky

Allicin, the main organic allyl sulfur component in garlic, exhibits immune-stimulatory and antitumor properties. Allicin stimulated [(3)H]thymidine incorporation in mouse splenocytes and enhanced cell-mediated cytotoxicity in human peripheral mononuclear cells. Multiple administration (i.p.) of allicin elicited a marked antitumor effect in mice inoculated with B-16 melanoma and MCA-105 fibrosa...

2016
Dina M. Metwally Ebtesam M. Al-Olayan Manal F. El-Khadragy Badriah Alkathiri

BACKGROUND Leishmania is a unicellular protozoan parasite that produces several human diseases, ranging from localized self-healing cutaneous lesions to deadly visceral infections. OBJECTIVE The effect of allicin on the growth of Leishmania major (L. major) promastigotes was evaluated under in vitro conditions. Moreover, the efficacy of a topical allicin cream was examined in BALB/c (Bagg alb...

2015
Xueqing Wu Regiane R Santos Johanna Fink-Gremmels

To demonstrate different effects of garlic extracts and their main antibiotic substance allicin, as a template for investigations on the antibacterial activity of food ingredients. Staphylococcus epidermidis ATCC 12228 and the isogenic biofilm-forming strain ATCC 35984 were used to compare the activity of allicin against planktonic bacteria and bacterial biofilms. The minimal inhibitory concent...

Journal: :Pathobiology : journal of immunopathology, molecular and cellular biology 2005
Ayelet Gonen Dror Harats Aharon Rabinkov Talia Miron David Mirelman Meir Wilchek Lev Weiner Esfir Ulman Hana Levkovitz Dikla Ben-Shushan Aviv Shaish

OBJECTIVE Garlic (Allium sativum) has been suggested to affect several cardiovascular risk factors. Its antiatherosclerotic properties are mainly attributed to allicin that is produced upon crushing of the garlic clove. Most previous studies used various garlic preparations in which allicin levels were not well defined. In the present study, we evaluated the effects of pure allicin on atherogen...

Journal: :Experimental and therapeutic medicine 2018
Yangfeng Xiang Jianqiang Zhao Ming Zhao Kejing Wang

Allicin has been reported to inhibit cancer cell proliferation, induce cell apoptosis and enhance the accumulation of reactive oxygen species. However, it has remained elusive whether allicin improves multidrug resistance in thyroid cancer cells through modulating autophagy. The present study demonstrated that combined use of allicin and cisplatin or carboplatin resulted in an enhanced growth i...

2014
Haohan Zhai Jianchao Pan En Pang Bo Bai

BACKGROUND AND AIM The present anti-infection strategy for prosthetic joint infections (PJI) includes the use of antibiotics and surgical treatments, but the bacterial eradication rates are still low. One of the major challenges is the formation of biofilm causing poor bacterial eradication. Recently it has been reported that allicin (diallyl thiosulphinate), an antibacterial principle of garli...

2014
Kenneth Chong Martha P. Zamora Dileshni A. Tilakawardane Nancy E. Buckley James A. Rego Yan Liu

Aims: The aims of this work were to quantify allicin an abundant antioxidant in different aqueous garlic extract samples and to determine the stability of allicin in the extract under different thermal and solvation conditions. Study Design: Descriptive research. Place and Duration of Study: Department of Chemistry and Biochemistry and Department of Biological Sciences, California State Polytec...

2017
Runxiao Lv Lili Du Chunwen Lu Jinhui Wu Muchen Ding Chao Wang Ningfang Mao Zhicai Shi

Allicin is a major bioactive ingredient of garlic and has a broad range of biological activities. Allicin has been reported to protect against cell apoptosis induced by H2O2 in human umbilical vein endothelial cells. The present study evaluated the neuroprotective effect of allicin on the H2O2-induced apoptosis of rat pheochromocytoma PC12 cells in vitro and explored the underlying mechanism in...

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