A method is described on the basis of a modification of the granddaughter design to obtain estimates of quantitative trait loci (QTL) allele frequencies in dairy cattle populations and to determine QTL genotypes for both homozygous and heterozygous grandsires. The method is based on determining the QTL allele passed from grandsires to their maternal granddaughters using haplotypes consisting of...

The aim of this study was to investigate effects of DGAT1, OPN and PPARGC1A candidate genes on milk production traits in Iranian Holstein cattle. Several papers have studied single nucleotide polymorphisms (SNPs) and their association with economic traits in dairy cows, but the combined effect of these genes has not been examined in Iranian Holstein cattle population. Blood samples were collect...

. the results of multiple qtl mapping design in recent years indicated quantitative trait loci for milk fat percentage and milk yield traits identified in bta14. dgat1 gene coding diacylglycerol-acyltransferase enzyme, has a main role in the triglyceride synthesis and finally fat milk synthesis. a transition mutation in this gene results substitution of guanine by adenine in the gene causing su...

the structure and properties of niobapyrimidinium complex were examined by density functionaltheory method (mpw1pw91). the effect of solvent on the structural parameters, frontier orbitalenergies and hyperpolarizability (
tot) of this molecule has been explored. the thermodynamicproperties of the title compound at different temperatures have been calculated. also, the parasubstitutionseffect on...

Quantitative traits locus for milk production traits has been described on centromeric end of bovine chromosome 14. Reports name the acyl coA: diacylglycerol acyltransferase (DGAT1) gene as a potential candidate gene with dinucleotide substitution (AA to GC) in exon VIII which causes the change of lysine to alanine in amino acid (K232A).The aim of the present study was to estimate the frequency...

Calpastatin (CAST) is a naturally occurring protein that inhibits the normal tenderization of meat as it ages postmortem. A SNP was identified in the CAST gene (a G to C substitution) and genotyped on crossbred commercially fed heifers (n = 163), steers (n = 226), and bulls (n = 61) from beef feedlots, and steers (n = 178) from a University of Guelph feeding trial. The association of the CAST S...

The sojourn times until fixation of an overdominant allele were investigated based on the diffusion equation. Furthermore, the rate of accumulation of mutations, or the substitution rate, was predicted from the mean extinction time of a common overdominant allele. The substitution rate calculated theoretically agreed well with that determined by computer simulation. Overdominant selection enhan...

Homozygosity for a large deletion in the solute carrier family 45, member 2 (SLC45A2) gene causes oculocutaneous albinism (OCA) in the Doberman Pinscher breed. An albino Lhasa Apso did not have this g.27141_31223del (CanFam2) deletion in her SLC45A2 sequence. Therefore, SLC45A2 was investigated in this female Lhasa Apso to search for other possible variants that caused her albinism. The albino ...

This study presents a new method that combines QTL mapping and gene introgression. The effectiveness of this method for simultaneous detection and introgression of a desirable QTL from a donor line into a recipient line was evaluated by simulation. For evaluation, we used the fourth backcross generation of 2 inbred lines. The difference between the 2 lines for the trait of interest was describe...