introduction: previous studies have shown that vitamin a and its derivatives such as retinoid and all-trans retinoic acid have a crucial role in memory, learning and synaptic plasticity. the receptors of vitamin a are seen in different parts of the brain such as hippocampus, where vitamin a has an important role in learning. in this study, the effect of intrahippocampal (ca1) injection of all –...

Introduction: Previous studies have shown that vitamin A and its derivatives such as retinoid and all-trans retinoic acid have a crucial role in memory, learning and synaptic plasticity. The receptors of vitamin A are seen in different parts of the brain such as hippocampus, where vitamin A has an important role in learning. In this study, the effect of intrahippocampal (CA1) injection of al...

patients with acute myeloblastic leukemia (aml) with monosomy 7 are a group of patients with refractory aml who have a very poor prognosis. therefore, rationally designed new therapies, including metronomic chemotherapy regimen with histidine deacetylase inhibitors (valporic acid, atra) are being investigated as potential treatments for the population of refractory cases of aml. herein, we repo...

introduction: retinoid signaling has been argued to have favorable effects on alzheimer's disease (ad). we studied the role of chronic intracerebroventricular (icv) injection of all-trans retinoic acid (atra) on the amyloid-beta (aβ) model of ad. methods: adult male rats weighing 260-330 g were divided into 12 groups of 8 each. six groups of rats received atra (3nm, 30nm, 3μm, 0.3mm, 30mm/...

a topical o/w cream containing tretinoin microspheres was prepared. gelatin microspheres of tretinoin were prepared using coacervation method. these microspheres contained about 50% w/w tretinoin. the particle size range of microspheres was between 90-150 m m. in vitro drug release from microspheres and a cream formulation was studied. it was shown that drug release from microspheres followed h...