conclusions alendronate may be considered a therapeutic option for improving the bone formation process and reducing resorption in different bone grafting procedures. further detailed studies should focus on dosage and time-dependent effects of alendronate on bone remodeling. results at 6 weeks, the bone area was significantly larger in the xenograft-alendronate group (33.0% ± 5.0%) than in the...

Clinical studies indicate that proton pump inhibitors (PPIs), used long-term in elderly patients, increase the risk of osteoporotic fractures, and decrease the anti-fracture efficacy of alendronate. The aim of the present study was to examine the effect of physical exercise on the anti-osteoporotic efficacy of alendronate administered concurrently with lansoprazole, a PPI, in male rats with and...

the present study assessed the real life therapeutic effects of weekly doses of alendronate in treating a group of osteoporotic patients in iran. the present historical cohort was conducted on patients who had undergone two or more bone mineral densitometry within an interval of 1.5-2 years in shariati hospital bone mineral density department between 2002 and 2010.patients were asked by phone a...

The objective of this study was to compare the disintegration times among Canadian-marketed brand (alendronate 70 mg, alendronate 70 mg plus vitamin D 5600 IU, and risedronate 35 mg) and generic (Novo-alendronate 70 mg and Apo-alendronate 70 mg) once-weekly dosed bisphosphonates. All disintegration tests were performed with a Vanderkamp Disintegration Tester. Disintegration was deemed to have o...

OBJECTIVE Compare in vitro and in vivo characteristics and clinical outcomes of brand and generic alendronate. RESEARCH DESIGN AND METHODS Relevant search terms were input into Medline ("alendronate" AND "generic" up to August 5, 2013) and any abstracts deemed possibly relevant selected for full paper review and abstraction. RESULTS Multicentre, randomized, placebo-controlled Phase III clin...

INTRODUCTION Since alendronate became available in generic form in the Unites States in 2008, its price has been decreasing. The objective of this study was to investigate the impact of alendronate cost on the cost-effectiveness of osteoporosis screening and treatment in postmenopausal women. METHODS Microsimulation cost-effectiveness model of osteoporosis screening and treatment for U.S. wom...

OBJECTIVE Increasing evidence suggests long-term alendronate use may overly suppress bone metabolism, limiting repair of microdamage and creating risk for insufficiency fractures. The purpose of this study is to demonstrate an association between alendronate use and a specific pattern of low-energy femoral shaft fracture. DESIGN, SETTING, AND PATIENTS A retrospective review was performed of p...

BACKGROUND Teriparatide is a promising new agent for the treatment of osteoporosis. METHODS The objective of this study was to evaluate the cost-effectiveness of teriparatide-based strategies compared with alendronate sodium for the first-line treatment of high-risk osteoporotic women. We developed a microsimulation with a societal perspective. Key data sources include the Study of Osteoporot...

BACKGROUND Alendronate can induce esophagitis and stomach ulceration requiring the concurrent use of drugs which decrease HCl production. The aim of the present study was to investigate the effect of concurrent administration of proton pump inhibitors, omeprazole or pantoprazole, and alendronate on the mechanical properties of long bones in bilaterally ovariectomized (OVX) rats. METHODS The e...