pharmacokinetic/pharmacodynamic (pk/pd) relationships describe the quantitative relationships between the drug-induced effects and the concurrent corresponding drug concentrations in an individual. since a long time, rough qualitative relationships have been described between neurological presentation and plasma ethanol concentration in acute ethanol ingestion. however, to date, precise quantit...

Autonomic nervous system integrity has been assessed in 30 alcoholic subjects and 30 age-sex matched controls using five simple tests of cardiovascular responses. There was evidence of parasympathetic neuropathy alone in five of the alcoholic subjects (16%) and of combined parasympathetic and sympathetic neuropathy in an additional six (20%). None of the controls showed any abnormality. Within ...

A consecutive sample of 76 chronic alcoholic patients was studied clinically, biochemically and electrophysiologically to assess clinical and/or subclinical signs of alcohol-related neuropathy as well as the most important and disputed risk factors for neuropathy such as age, parental history of alcoholism, nutritional status, alcoholic disease duration and total lifetime dose of ethanol (TLDE)...

BACKGROUND Autonomic neuropathy has been reported in patients with alcoholic liver disease but information on its occurrence in patients with non-alcoholic liver disease is contradictory. AIM To assess autonomic functions in patients with alcoholic and non-alcoholic liver disease. STUDY DESIGN Autonomic function using five standard tests was examined in 20 cirrhotics (10 alcoholics and 10 n...

may cause peripheral nerve dysfunction suggests that lack of these or other B-complex vitamins may also contribute to neuropathy in the malnourished alcoholic. The present investigation was therefore undertaken to evaluate further the role of aneurin and other B-complex vitamins in the development of this condition. The study consisted of (a) determining circulating levels of aneurin, riboflavi...

SYMMMS of alcoholic Peripheral neuropathy were first recognized by ' S Lettsom (1787) who described hypermsthesiae and paralysis, affecting the ` r legs more than the arms. He, and later Jackson (1822), delineated the late ^ ^y ^ G^ `^ stage of peripheral nerve affection. Much clinical observation since then ','^ .c 0 has shown that the neuropathy in alcoholics varies widely in seve rity. We S ...

Cardiac vagal reflexes were studied in 11 alcoholic subjects, 1 to 6 weeks after withdrawal and again after up to 27 months of continued abstinence. On initial investigation six subjects had vagal neuropathy. On the second occasion only two subjects had vagal neuropathy and significant improvement was seen in the total patient group with regard to heart rate responses to standing, Valsalva's ma...