objective eudragits are widely used polymers in the production of oral sustained release dosage forms. the application of these polymers in the production of inert insoluble matrices has been investigated. however the effect of particle size, compaction force and presence of aerosil 200 as a glidant on the properties of eudragit rs and rl matrices prepared by direct compression of their physica...

Objective Eudragits are widely used polymers in the production of oral sustained release dosage forms. The application of these polymers in the production of inert insoluble matrices has been investigated. However the effect of particle size, compaction force and presence of Aerosil 200 as a glidant on the properties of Eudragit RS and RL matrices prepared by direct compression of their physica...

A bilayer tablet formulation approach was used to develop a fixed dose combination tablet formulation of drugs Y & Z. The weight of Layer I containing Drug Y and the weight of Layer II A or II B containing Drug Z were 250 mg and 1280 mg, respectively. While Layer I was manufactured using dry granulation, Layer II A and II B were manufactured using a moisture activated dry granulation (MADG) pro...

Objective Eudragits are widely used polymers in the production of oral sustained release dosage forms. The application of these polymers in the production of inert insoluble matrices has been investigated. However the effect of particle size, compaction force and presence of Aerosil 200 as a glidant on the properties of Eudragit RS and RL matrices prepared by direct compression of their physic...

High-resolution ac calorimetry has been carried out on dispersions of aerosils in the liquid crystal octyloxycyanobiphenyl (8OCB) as a function of aerosil concentration and temperature spanning the crystal to isotropic phases. The liquid crystal 8OCB is elastically stiffer than the previously well studied octylcyanobiphenyl (8CB)+aerosil system and so general quenched random-disorder effects an...

The physicochemical characteristics and oral absorption of a poorly water-soluble drug, K-832, adsorbed onto porous silica (Sylysia 350), were compared with those of K-832 adsorbed onto non-porous silica (Aerosil 200). K-832 and silica were treated with supercritical CO(2) (scCO(2)) to produce K-832-Sylysia 350 and K-832-Aerosil 200 formulations. Scanning electron microscopy, polarizing microsc...

High-resolution ac calorimetry has been used to study the nematic to smectic- A (N-SmA) phase transition in the liquid crystal octylcyanobiphenyl (8CB) confined in aligned colloidal aerosil gels. A stable and robust nematic alignment was achieved by repeated thermal cycling of the samples in the presence of a strong uniform magnetic field. In some ways (such as transition temperature and integr...

The basic principle of liquisolid systems formulation lies in the conversion of the drug in a liquid state into an apparently dry, free-flowing and readily compressible powder by its blending (or spraying) with specific carriers and coating materials. The selection of the most suitable carrier and coating material depends especially on their values of flowable liquid retention potential (Φ), wh...

A facile spray drying technique has been developed for large-scale and template-free production of nanoporous silica with controlled morphology, large pore size, and high pore volume, using commercially available fumed silica, Aerosil 200, as a sole precursor. This approach can be applied to the preparation of functional nanoporous materials, in this study, lanthanum oxide functionalised silica...