background pharmacovigilance (pv) data are crucial for ensuring safety and effectiveness of medicines after drugs have been granted marketing approval. this paper describes the pv systems of india, uganda and south africa based on literature and key informant (ki) interviews and compares them with the world health organization’s (who’s) minimum pv requirements for a functional national pv syste...

background : following establishment of iranian adverse drug reaction (adr) monitoring  center  in  1997, adr  committees  were  established  in  all  hospitals  of mazandaran province of iran. clinical pharmacists from mazandaran university of medical sciences have been involved with these committees since 2007. the aim of this study was to compare the results of the pharmacovigilance system b...

Adverse drug reactions (ADRs) are considered as one of the leading causes of death among hospitalized patients. Thus reporting of adverse drug reactions become an important phenomenon. Spontaneous adverse drug reaction reporting form is an essential component and a major tool of the pharmacovigilance system of any country. This form is a tool to collect information of ADRs which helps in establ...

detection of probable harmful consequences arised from the usage of pharmaceutical products requires decisive, continuous and close monitoring by medical staff whom should have knowledge of adverse drug reactions and they should also have to report any suspected instances, when any kind of adverse drug reactions have been observed. this study has been carried out on the knowledge, attitude and ...

background : adverse drug reactions (adr) are ranked as some of the major causes of patient morbidity and mortality. spontaneous reporting of adrs has remained the cornerstone of pharmacovigilance and is important in maintaining patient safety. this study was conducted to assess the nurses’ knowledge and attitude towards pharmacovigilance, reasons for not reporting adrs, and their pharmacovigil...

Adverse drug reactions (ADRs) are noxious and unexpected effects during normal drug therapy. They have caused significant clinical burden and been responsible for a large portion of new drug development failure. Molecular understanding and in silico evaluation of drug (or candidate) safety in laboratory is thus so desired, and unfortunately has been largely hindered by misuse of ADR terms. The ...

In this paper we develop an optimization approach for the study of adverse drug reaction (ADR) problems. This approach is based on drug–reaction relationships represented in the form of a vector of weights, which can be defined as a solution to some global optimization problem. Although it can be used for solving many ADR problems, we concentrate on two of them here: the accurate identification...

Adverse drug reactions adverse drug reaction (ADR) occur in approximately 17% of patients. Avoiding ADR is thus mandatory from both an ethical and an economic point of view. Whereas, pharmacogenetics changes of the pharmacokinetics may contribute to the explanation of some type A reactions, strong relationships of genetic markers has also been shown for drug hypersensitivity belonging to type B...

This paper describes our system used in the PSB 2016 Workshop on Social Mining Shared Task for adverse drug reaction (ADR) extraction in Twitter. Our system uses Conditional Random Fields to train a classifier for extracting ADR mentions. We leverage word representations from large amount of unlabeled tweets, both drug related and generic. Our experiment results show that cluster features deriv...