FT-SERS (Fourier Transform Surface Enhanced Raman Scattering) of adriamycin and its complex with DNA is reported. It is shown that in agreement with previous Raman studies the interaction of adriamycin  with DNA takes place through an intercalation mechanism. The presence of a new band at 731 cm-1 suggests that ring D of adriamycin is not involved in the intercalation process.

ft-sers (fourier transform surface enhanced raman scattering) of adriamycin and its complex with dna is reported. it is shown that in agreement with previous raman studies the interaction of adriamycin  with dna takes place through an intercalation mechanism. the presence of a new band at 731 cm-1 suggests that ring d of adriamycin is not involved in the intercalation process.

Introduction: Although the effect of adriamycin, a chemical drug used to treat cancer, is known to affect gametogenesis and ovarian function, the drug’s effect on endometrial receptivity and expression of integrin genes is unclear. To fill this gap, we aimed to investigate the effect of adriamycin on the expression of integrin genes that play a role in endometrial receptivity. Methods: A total...

introduction: the aim of the study was to investigate the effects of curcuma longa (c. longa) extract on adriamycin-induced hepatotoxicity in rat. methods: animals were divided in six groups: control (co), adriamycin (adr), adriamycin with vitamin c (adr+vitc), vitamin c (vit c), c. longa with adriamycin (cl+adr) and without adriamycin (cl-adr). hepatotoxicity was induced by adriamycin 5mg/kg a...

Introduction: The aim of the study was to investigate the effects of Curcuma longa (C. longa) extract on Adriamycin-induced hepatotoxicity in rat. Methods: Animals were divided in six groups: Control (CO), Adriamycin (ADR), Adriamycin with Vitamin C (ADR+VitC), Vitamin C (Vit C), C. longa with Adriamycin (CL+ADR) and without Adriamycin (CL-ADR). Hepatotoxicity was induced by Adriamycin 5mg/kg ...

isotherms of the binding of the anthracyciine antibiotic, adriamycin (adriblastin), to dna histone complexes was studied by means of spectroscopic analysis. the results indicated that: (a) binding of adriamycin to histones reduced the interaction of histones with dna, (b) binding of the drug to dna did not change the binding affinity of histone to dna and, (c) in the explored binding range of r

Objective. This study aimed to investigate the effects of Nephropathy Prescription I on expression angptl3, nephrin, and podocin, in addition its protective podocytes mice with adriamycin-induced nephropathy. Methods. BALB/c were randomly divided into control (C), adriamycin (Model or M), + (M Z), prednisone acetate S), groups Z S). All except those C group experimental treated a single tail ve...

BACKGROUND Nephrosis-induced endothelial dysfunction is assumed to play a main role in cardiovascular morbidity. Adriamycin-induced proteinuria is a well-established rat model for nephrotic syndrome. However, induction of nephrosis by intravenous adriamycin administration might exert direct adriamycin cardiovasculotoxicity that could obscure or modify nephrosis-induced vascular dysfunction. The...

objective: inflammation and oxidative stress is considered to have a crucial role in induction of nephropathy. curcuma longa (c. longa) and nigella sativa (n. sativa) have anti-inflammatory and antioxidant effects. this study was designed to investigate the effect of mixed hydro-alcoholic extract of n.sativa and c. longa on the oxidative stress induced by adriamycin (adr) in rat kidney. materia...

Background: Breast cancer is in women with the highest incidence. Adriamycin-cyclophosphamide (AC) chemotherapy a breast therapy good efficacy, but its effectiveness has not been maximized. The okra fruit extract known to have anti-cancer effects from lectins, so it can be used as complementary increase minimal side effects.
 Methods: This study an experimental using female rats Sprague Da...