background:chronic active adrenocorticotropin hormone (acth) immunization of ewes (with a previous history of immunization) resulted in elevated titres of antibody against acth, which induced a reduction in circulating levels of cortisol. objectives:the aim of the present study was to investigate: a) the influence of active immunization against acth on milk production of the ewe as assessed by ...

A patient with adenocarcinoma of the stomach and recurrent hypoglycemia is presented. The fasting blood sugar ranged from lOm/100,ml to 35mg/100 and the serum insuline levels ranged from 24 miU/ml to  42 miu/ml. The counterregulatory hormones(growth hormone, cortisol, adrenocorticotropin hormone) levels were within normal limits. No significant hepatic involvement was observed in isotopic live...

BACKGROUND Copeptin (pre-proAVP) secreted in equimolar amounts with vasopressin closely reflects vasopressin release. Copeptin has been shown to subtly mirror stress potentially mediated via corticotrophin-releasing hormone. To further test a potential direct interaction of corticotrophin-releasing hormone with copeptin release, which could augment vasopressin effects on pituitary function, we ...

We compared the activity and responsiveness of the hypothalamo-pituitary-adrenal (HPA) axis of an urban (Phoenix, Arizona) and desert population of a male songbird species (Curve-billed Thrasher, Toxostoma curvirostre), by measuring plasma corticosterone in response to acute administration of corticotropin-releasing factor, arginine vasotocin, or adrenocorticotropin hormone. Urban adult male th...

Neuroendocrine complications are among important and frequently missed complications of traumatic brain injury. Hypopituitarism, the partial or complete insufficiency of anterior pituitary secretion may be underrecognized due to its subtle clinical manifestations in traumatic patients. We report a case of 14.5-year-old girl who was admitted due to growth failure and had been diagnosed to have m...

To test whether angiotensinogen might be targeted to dense core secretory granules in cells containing a regulated secretory pathway, we expressed rat angiotensinogen in AtT-20 cells, a mouse pituitary cell line that has the demonstrated ability to correctly sort proteins to the constitutive or regulated pathway. We compared the pattern of secretion of angiotensinogen with that of endogenous ad...

Amber, a plant resin, exhibits an anti-stress effect and is used in traditional medicine. Recently, it has been speculated that amber may possess anti-depressive effect. However, there no evidence to support this efficacy. Thus, study investigated the oxidative-stress-ameliorating effects of extract mice subjected restraint stress. Mice were treated with (25 50 mg/kg, p.o.) bupropion (10 as pos...

pituitary tumors in situ, AtT-20/NYU-1 cells were found to produce the alpha subunit of the glycoprotein hormones (alpha). Alpha accumulation in the medium was constant (3.1 ng/mg cell protein per h) and was not affected by TRH. In contrast, TRH increased the amount of ACTH accumulated in the medium from AtT-20/NYU-1 cells to 190 and 420% of control at 1 and 24 h, respectively. TRH induced a do...

Antibodies directed against human follicle-stimulating hormone (FSH) were demonstrated in rabbit serum by neutralization of biological activity. Antibodies that bound FSH-(131)I were produced in rabbits and guinea pigs by repeated injections of FSH. By (131)I immunochemical methods, we found that at least 90% of the FSH-(131)I-binding antibody failed to distinguish the four human glycoprotein h...