cushing’s syndrome (cs) occurs rarely during pregnancy. cs can be caused by prolonged abnormal exposure to excess glucocorticoids leading to special and significant signs and symptoms. it is often difficult to diagnose pathological hypercortisolism in pregnant women since some symptoms of the disease might be due to a complicated pregnancy, including preeclampsia or gestational diabetes. in thi...

a 64-year-old male presented with neurofibromatosis 1 and cushing’s syndrome. clinically he was over weight, depressed with extensive skin bruising and hypertension. his 24 hours urinary metanephrines, urinary 5hiaa, gut peptides and chromgranin levels were normal. his renal function and renal mri scan was also normal. his cortisol failed to suppress on overnight dexamethsone suppression test. ...

Transgenic (TG) female mice expressing bLHbeta-CTP (a chimeric protein derived from the beta-subunit of bovine luteinizing hormone [LH] and a fragment of the beta-subunit of human chorionic gonadotropin [hCG]) exhibit elevated serum LH, infertility, polycystic ovaries, and ovarian tumors. In humans, increased LH secretion also occurs in infertility and polycystic ovarian syndrome, often concomi...

Cushing’s syndrome (CS) occurs rarely during pregnancy. CS can be caused by prolonged abnormal exposure to excess glucocorticoids leading to special and significant signs and symptoms. It is often difficult to diagnose pathological hypercortisolism in pregnant women since some symptoms of the disease might be due to a complicated pregnancy, including preeclampsia or gestational diabetes. In thi...

OBJECTIVE This article aims to show the imaging characteristics of pediatric adrenocortical tumors. MATERIAL AND METHODS We review the imaging and histological findings in patients diagnosed with pediatric adrenocortical tumors at our tertiary hospital between 2000 and 2010. We analyze the findings at ultrasonography, computed tomography, and magnetic resonance imaging that can help orient th...

BIOCHEMICAL DERANGEMENTS resulting from adrenal cortical hyperfunction or from critical reduction of the endogenous corticosteroid hormone supply are sometimes overshadowed by major disturbances of cardiovascular function. Arterial hypertension and congestive heart failure may be the predominanit presenting clinical features in patients with adrenal cortical hyperfunction. During acute illness ...

Continues on page 26 One of the most frequently asked questions regarding phlebotomy is, why are the potassiums high? The answer involves a variety of factors, which can have a significant impact on the care of a patient. When an abnormally high value exists, it frequently sets off a train of investigations looking for such severe diseases as: renal failure; adrenocortical hypofunction; and dia...

Introduction It is well known that pregnancy is associated with an increase in plasma cortisol and that especially in the third trimester the values attained resemble a state of adrenocortical hyperfunction (Kopelman & Levitz, 1970). It has also been shown that the concentration of cortisol in cord blood reflects the maternal state although it is less than the corresponding maternal values and ...