nonfunctional adrenocortical carcinoma is an extremely rare malignant tumor in children. unlike the functional tumor which is detected early due to its hormonal presentation, nonfunctional tumor is detected at a later stage. here we report a case of a 10 year old girl who presented with abdominal mass and symptoms of short duration. no hypertension and cushingoid features were seen. serum alpha...

PURPOSE: Adrenocortical adenomas are common, whereas adrenocortical carcinomas are rare. Discriminating between benign and malignant adrenocortical tumors using conventional histology can be difficult. In addition, adrenocortical carcinomas generally have poor prognosis and limited treatment options. MicroRNAs are short noncoding RNAs that are involved in regulation of gene transcription. EXPER...

Although adrenocortical tumors are common, adrenocortical carcinomas are rare. Moreover, aldosterone-producing adrenocortical carcinomas without hypertension are exceedingly rare, with only two previously reported cases.

Nonfunctional adrenocortical carcinoma is an extremely rare malignant tumor in children. Unlike the functional tumor which is detected early due to its hormonal presentation, nonfunctional tumor is detected at a later stage. Here we report a case of a 10 year old girl who presented with abdominal mass and symptoms of short duration. No hypertension and cushingoid features were seen. Serum alpha...

Using immunoperoxidase methods, 94 human adrenal tumors were examined for evidence of immunoreactivity and receptor expression of insulinlike growth factor I (IGF-I) and insulin. The frequency of IGF-I in adrenocortical carcinomas was significantly higher than that in adenomas of the adrenal glands. The adrenocortical carcinomas showed strong intensity of staining for IGF-I, IGF-I receptors, an...

Low H19 and abundant IGF-II expression may have a role in the development of adrenocortical carcinomas. In the mouse, the H19 promoter area has been found to be methylated when transcription of the H19 gene is silent and unmethylated when it is active. We used PCR-based methylation analysis and bisulfite genomic sequencing to study the cytosine methylation status of the H19 promoter region in 1...

Adrenocortical cancer is a rare cancer with a very poor prognosis. The genetic alterations identified to date in adrenocortical tumors are limited. Activating mutations of the Wnt signaling pathway have been observed in more frequent cancers, particularly digestive tract tumors. We investigated whether Wnt pathway activation is involved in adrenocortical tumorigenesis. In a series of 39 adrenoc...

The histopathologic features of 10 myxoid adrenocortical neoplasms were analyzed, and epidermal growth factor receptor (EGFR) expression, EGFR gene copy number, and EGFR gene mutations in the 10 tumors were detected by using immunohistochemical analysis, fluorescence in situ hybridization, and the Scorpion Amplification Refractory Mutation System (DxS, Manchester, England), respectively. Histol...

BACKGROUND The aim of this study was to assess the metallothionein (MT), maintenance protein 2 (Mcm-2) and Ki-67 expressions in adrenocortical adenomas and carcinomas in comparison to normal tissue and evaluate the correlations between these markers of proliferation and between these markers and tumor diameter. MATERIALS AND METHODS The expression of MT, Mcm-2 and Ki-67 was assessed by immuno...

Adrenocortical tumors (ACT) include both adrenocortical adenomas (ACA) and adrenocortical carcinomas (ACC). Carcinomas are rare in children and adolescents. In the United States, Surveillance Epidemiology and End Results (SEER) data from the National Cancer Institute show that the proportion of adrenocortical tumors (ACT) in childhood carcinoma is only about 1.3%, and the proportion of ACT in c...