The vast accumulation of literature relative to adrenalin glycosuria contains very few records of attempts to demonstrate a quantitative relationship between adrenalin administration and sugar elimination. For the most part investigators have been content with the knowledge that a certain quantity of adrenalin injected subcutaneously or intraperitoneally almost invariably causes the appearance ...

Preparations from the parotid gland venom of the toad Bufo marinus have been analyzed by paper chromatography for the presence of adrenalin precursors. In addition to adrenalin itself, hydroxytyramine was identified and a second compound which appeared to be an adrenalin ester-perhaps lactyl-adrenalin. Two other compounds which appeared on the chromatogram could not be identified. Neither norad...

The results of these experiments show, in short, that, by the method employed, adrenalin could neither be demonstrated in the specimen of blood, nor in either of the two specimens of malignant hypernephroma, nor in the specimen of metastatic tissue from the adrenal tumor which closely resembled a malignant hypernephroma. The results agree with those of Greer and Wells in showing that no adrenal...

1. Adrenalin when mixed with olive oil 1:100 and injected subcutaneously into a catfish will produce a marked pale spot and a general blanching of the whole fish. The general blanching will disappear in about a day. The pale spot may last 3 to 4 weeks. 2. Injections of adrenalin in oil 1:1000 to 1:10,000,000 cause the formation of only pale spots in catfishes. Adrenalin in oil 1:100,000,000 has...

Hyperglycemia was observed in frogs after single ip injections of doses above 50 &kg of adrenalin and glucagon. Blood glucose responses were maximal at 3 hr and lasted at least 5 hr. Lactacidemia was apparent after treatment with adrenalin at doses of 50 &kg and above. The increase in lactate was apparent by 1 hr and had dropped to control levels by 5 hr. Tissue giycogen loss was not observed a...

Wense has reported the isolation of crystalline adrenalin from larvae of the beetle Tenebrio molitor. An attempt to repeat his procedures failed to yield any evidence of adrenalin. Analysis of mealworm extracts by paper chromatography and colorimetric means also yielded no indication of adrenalin, though adrenalin added to mealworms can be detected by these procedures in amounts less than 1 mg....

In a previous paper, 1 I concluded that no proof had hitherto been given that adrenalin is ever present in detectable amount in normal sera from the general circulation. I have since examined by similar methods a number of sera from clinical cases. In the first paper, the literature on the alleged detection of adrenalin in pathological sera and the so-called estimation of the variations in the ...

It has been reported from this laboratory (1) that a deficiency of vitamin C in guinea pigs leads to changes in carbohydrate metabolism, as evidenced by glycosuria, a diabetic type of the glucose tolerance curve, and depletion of the glycogen content of the liver. We have also found that there is a fall in the insulin content of the pancreas (2), an increase in the size and also the number of i...

Physiological recordings were taken while 16 psychopaths (P), 16 nonpsychopaths (NP), and 16 "mixed" (M) 5s received an injection of saline, followed 15 min. later by an injection of adrenalin. Tonic skin conductance of Group NP was generally greater than that of Groups M and P, a difference that increased throughout the course of the experiment. There were no significant group differences in t...

The adrenalin index as used in this paper means the amount of adrenalin in milligrams per gram of gland. As in our hands the chemical colorimetric method has proved more accurate, these values rather than the physiological values will be given in the final analysis. The two adrenal glands in the same individual as a rule contain about the same amount of adrenalin per gram, but variations of 10 ...