acute myeloblastic leukemia is one of the important malignancies in children. for better managing the prognosis of this disease, there should be enough information about common features of this malignancy. the aim of this study was to evaluate these common features in children with acute myeloblastic leukemia. a total of 104 eligible children less than 15-year-old have been referred from 2007-2...

introduction: gtpase regulator associated with focal adhesion kinase (graf) is a recently identified gtpase activating protein that has the tumor suppressor properties. however, the expression level of graf in leukemia had received less attention. the main purpose of this research was the evaluating of the expression level of graf in patients with acute myeloid leukemia (aml). materials and met...

background: treatment of cancer patients using conventional chemotherapy causes serious side effects and, at best, merely extends the patient’s lifespan by a few years. the potential of alternative therapies may therefore be of great benefit in cancer control. the effect of trigonella foenum graecum seed extract has been previously reported on some neoplastic cells. here, its effect is evaluate...

Background: In acute myeloblastic leukemia, a large number of tumor suppressor genes are silenced through DNA methylation such as CDKN2B & p73. Wnt inhibitory factor 1 (WIF1) and Dickkopf-3 (DKK-1) are negative regulators of Wnt signaling pathway. In the present study, we evaluated the methylation status of WIF1 and DKK-1 genes in acute myeloblastic leukemia patients. Patients and Methods: ...

background:alpha-synuclein is a member of synuclein family of proteins with unidentified function localized in the cytoplasm, mitochondria of neurons, and presynaptic nerve endings. although it is found in the lewy bodies in synucleinopathies and in alzheimer’s disease, the protein could also be considered as a novel marker in diagnosis of diseases related to the hematopoietic system. methods: ...

background: wnt molecules play a key role in growth, proliferation and development of some embryonic and adult organs as well as hematopoietic stem cells. wnt signaling pathways are aberrantly activated in many tumor types, including solid tumors and hematologic malignancies. objective: to investigate the expression profile of a large number of wnt genes in leukemic cells from iranian patients ...

homogeneously staining regions (hsr) or double minute chromosomes (dmin) are autonomously replicating extra-chromosomal elements that are frequently associated with gene amplifi cation in a variety of cancers. the diagnosis of leukemia patients was based on characterization of the leukemic cells obtained from bone marrow cytogenetics. this study report two cases, one with acute myeloblastic leu...

I N CHRONIC GRANULOCYTIC LEUKEMIA neurologic manifestations due to leukemic infiltration of the central nervous system occur uncommonly.’ In acute lymphoblastic leukemia, on the other hand, diffuse leukemic infiltration of the lepto-meninges is frequent and must be differentiated from neurologic involvement due to infection, hemorrhage, or drug toxicity.2 \Vhen acute myeloblastic transformation...

background: in acute myeloblastic leukemia, a large number of tumor suppressor genes are silenced through dna methylation such as cdkn2b & p73. wnt inhibitory factor 1 (wif1) and dickkopf-3 (dkk-1) are negative regulators of wnt signaling pathway. in the present study, we evaluated the methylation status of wif1 and dkk-1 genes in acute myeloblastic leukemia patients. patients and methods: bloo...

introduction: acute myelogenous leukemia (aml) is a clonal  malignant disease of hematopoietic tissue. the early use of  hematopoietic stem cell transplantation (hsct) for aml was for patients with advanced stages of disease, usually while in relapse, in second or subsequent remission, or with resistant disease. patients and methods: from march 1991 until february 2008, 356(65%) registered allo...