Mycotoxins severely threaten the health of humans and animals. For this reason, many countries have enforced regulations and recommendations to reduce the dietary exposure. However, even though regulatory actions must be based on solid scientific knowledge, many aspects of their toxicological activity are still poorly understood. In particular, deepening knowledge on the primal molecular events...

No studies were located that examined health effects in humans or animals exposed to threeor fourmembered mixtures of the five components of concern. No PBPK models were found for threeor fourmembered mixtures of these chemicals. The following subsections present evaluations of health effects data and discussions of mechanistic information pertinent to the joint toxic action of each pair of com...

OBJECTIVE To investigate whether the lack of knowledge of toxic agents in households is a risk factor for individual unintentional childhood poisoning. METHODS The case group (n = 25) was composed of caregivers of children under 60 months of age who underwent accidental oral poisoning and were treated at two reference hospitals in Porto Alegre, southern Brazil, and recorded in the Toxicology ...

Interestingly, mechanism of toxic action on some target organs drugs and other substances proceedings of the european society of toxicology meeting held in berlin west june 25 28 1978 that you really wait for now is coming. It's significant to wait for the representative and beneficial books to read. Every book that is provided in better way and utterance will be expected by many peoples. Even ...

The ratification of the Stockholm Convention on Persistent Organic Pollutants is a departure point for several considerations on their presence in environmental matrices. In this paper, the Italian situation is presented with emphasis on the most toxic compounds--chemicals with dioxin-like toxic action, and the activity in the area of interest of the Istituto Superiore di Sanità. Biotic, as wel...

For the past several years we have been working with models of benzene distribution and metabolism, principally in the rat, but more recently in humans. Our biologically related objectives have been primarily to assist our laboratory-based colleagues in their quest for understanding of the mechanisms by which benzene exerts its toxic action. A secondary goal has been to develop or adapt models ...

The Drugs Rules, 1945, framed under the Drugs Act, 1940, are more or less an exact replica of the Statutory Rules and Orders made under the Therapeutic Substances Act of Great Britain. The question of the differences in susceptibility and reactivity of laboratory animals in India and England has not been taken into consideration. Taylor and Ahuja (1935) reported that ' White mice bred in Kasaul...

In this work we deal with actions of vector groupoid which is a new concept in the literature‎. ‎After we give the definition of the action of a vector groupoid on a vector space‎, ‎we obtain some results related to actions of vector groupoids‎. ‎We also apply some characterizations of the category and groupoid theory to vector groupoids‎. ‎As the second part of the work‎, ‎we define the notion...

Transfer protocols are composed from basic protocol mechanisms and accordingly a complex protocol can be veriied by a series of relatively simple mechanism proofs. Our approach applies L. Lamport's Temporal Logic of Actions (TLA). It is based on a modular compositional TLA-style and supports the analysis of exibly conngured high-speed transfer protocols.