it was thought previously that cardiac muscle gap junctions provide low-resistance connections between cells and permit the local-circuit current to flow. some evidences show that myocardial cells may not require low-resistance connections for successful propagation of the action potential (ap). it seems that some other types of mechanisms must be involved in ap propagation. in this article, we...

It was thought previously that cardiac muscle gap junctions provide low-resistance connections between cells and permit the local-circuit current to flow. Some evidences show that myocardial cells may not require low-resistance connections for successful propagation of the action potential (AP). It seems that some other types of mechanisms must be involved in AP propagation. In this article, we...

It was thought previously that cardiac muscle gap junctions provide low-resistance connections between cells and permit the local-circuit current to flow. Some evidences show that myocardial cells may not require low-resistance connections for successful propagation of the action potential (AP). It seems that some other types of mechanisms must be involved in AP propagation. In this article, we...

In the previous notes, we described the action potential for a “point” cell, so that we could use an ODE model. Here, we consider propagation of the action potential along an axon. Consider a system in which the intracellular and extracellular spaces are separated by a cell membrane. Let x be the one-dimensional spatial coordinate, and consider current conservation in the intracellular region c...

Glia affect neural circuits in numerous ways. Microglia strip synapses and clear debris after injury; oligodendrocytes form myelin, which regulates axon conduction velocity and limits sprouting; and astrocytes direct blood flow to active circuits, provide nutrients and growth factors, regulate extracellular ion concentrations, guide neurite growth, promote synaptogenesis, stabilize dendritic sp...

In this research we show that the dynamics of an action potential in a cell can be modeled with a linear combination of the dynamics of the gating state variables. It is shown that the modeling error is negligible. Our findings can be used for simplifying cell models and reduction of computational burden i.e. it is useful for simulating action potential propagation in large scale computations l...

Normal rat kidney (NRK) fibroblasts change their excitability properties through the various stages of cell proliferation. The present mathematical model was developed to explain excitability of quiescent (serum deprived) NRK cells. It includes as cell membrane components, based on patchclamp experiments, an inwardly rectifying potassium conductance (GKir), an L-type calcium conductance (GCaL),...

Many diverse studies have shown that a mechanical displacement of the axonal membrane accompanies the electrical pulse defining the action potential (AP). We present a model for these mechanical displacements as arising from the driving of surface wave modes in which potential energy is stored in elastic properties of the neuronal membrane and cytoskeleton while kinetic energy is carried by the...