Aconitine is a well-known arrhythmogenic toxin and induces triggered activities through cardiac voltage-gated Na(+) channels. However, the effects of aconitine on intracellular Ca(2+) signals were previously unknown. We investigated the effects of aconitine on intracellular Ca(2+) signals in rat ventricular myocytes and explored the possible mechanism of arrhythmogenic toxicity induced by aconi...

OBJECTIVE Pancreatic cancer is one of the leading causes of death from cancer in European countries and the United States. This study sought to investigate the effects of aconitine, a well-known aconitum plant-produced toxin, on pancreatic cancer cell growth and apoptosis and to explore the potential mechanisms. MATERIALS AND METHODS In this study, pancreatic cancer cell lines Miacapa-2 and P...

OHNO, Y., CHIBA, S., UCHIGASAKI, S., UCHIMA, E., NAGAMORI, H., MIZUGAKI, M., OHYAMA, Y., KIMURA, K. and SUZUKI, Y. The Influence of Tetrodotoxin on the Toxic Effects of Aconitine in vivo. Tohoku J. Exp. Med., 1992, 167 (2), 155158 Both aconite toxins (aconitine, mesaconitine, and hypaconitine) and a pufferfish toxin (tetrodotoxin, TTX) were detected in the blood of a legal autopsy case. In orde...

Under conditions of Na(+) channel hyperactivation with aconitine, the changes in action potential duration (APD) and the restitution characteristics have not been well defined in the context of aconitine-induced arrhythmogenesis. Optical mapping of voltage using RH237 was performed with eight extracted rabbit hearts that were perfused using the Langendorff system. The characteristics of APD res...

Aconitine is a main component of Aconitum carmichaeli, a Chinese herb known to be effective for arthritis and neuralgia. Many senior citizens consume the herb as a folk remedy. Aconitine-associated cardiogenic toxicity has been observed but aconitine-induced cerebrovascular event has not been reported so far. We report two elderly patients who became unconscious and showed neurological dysfunct...

INTRODUCTION Aconitine is a highly toxic diterpenoid alkaloid, produced by plants of the Aconitum genus, that is still used in Chinese herbal medicines. Aconitine poisoning remains common in China and other parts of Asia. CASE REPORT A 48-year-old man received a diagnosis of aconitine poisoning after ingesting herbal medicinal wine made with caowu, which is made from Aconitum kusnezoffii root...

In Asia, aconitine poisoning is common because of the continued use of aconite roots in traditional medicine as an analgesic, anti-inflammatory, and cardiotonic agent. Aconitine and other Aconitum alkaloids are highly poisonous cardio-toxins and neurotoxins present in all parts of the plants of the Aconitum genus (aconite). The major toxin in these plants is aconitine, which interacts with the ...

Certain characteristics of aconitine-induced auricular arrhythmias in dogs and the responses of aconitine-induced flutter to various experimental procedures and to drugs are described. In certain experiments there was evidence that a secondary flutter mechanism had developed which, in some instances, resembled flutter of circus-movement origin. When aconitine-induced and circus-movement flutter...

BACKGROUND Compatibility of Radix Aconiti Carmichaeli and Liquorice is known to treat heart diseases such as heart failure and cardiac arrhythmias. This work answers the question that whether the active components (Aconitine, Liquiritin and Glycyrrhetinic Acid) of Radix Aconiti Carmichaeli and Liquorice could result in regulating intracellular calcium homeostasis and calcium cycling, and thereb...

Certain characteristics of aconitine-induced auricular arrhythmias in dogs and the responses of aconitine-induced flutter to various experimental procedures and to drugs are described. In certain experiments there was evidence that a secondary flutter mechanism had developed which, in some instances, resembled flutter of circus-movement origin. When aconitine-induced and circus-movement flutter...