In connexion with studies on the N-terminal groups of histones (Phillips, 1961), a method was needed for measuring about 0-1 ,umole of aliphatic acyl groups derived from a few milligrams of protein. Initial experiments were done in which acetylamino acids and ovalbumin were hydrolysed in sulphuric acid and an ether extract was chromatographed, by using modifications of the method of Brown & Hal...

The iso-nicotinic acid hydrazides are valuable agents against tuberculosis exerting a powerful bacteriostatic action on the tubercle bacillus,’ diffusing readily into the cerebro spinal fluid,2 concentrating (as demonstrated by tissue cultures) effectively within macrophages3 and absorbed after oral administration without gastro-intestinal irritation. Such a combination of desirable attributes ...

PAGE Inhibition of the alanine-oxoglutaric acid transaminase of pig-heart muscle by cyclic hydrazides.

We have developed a new method for accurate quantification of dead microbial cells. This technique employs the simultaneous use of fluorescent hydrazides and nucleic acid dyes. Fluorescent hydrazides allow detection of cells that cannot be detected with currently used high-affinity nucleic acid dyes. This is particularly important for nongrowing bacterial populations and for multicellular commu...

Some derivatives of biphenyl-4-carboxylic acid 2-(aryl)-4-oxo-thiazolidin-3-yl –amide were synthesized and studied for their antimicrobial activity. These compounds were prepared from biphenyl-4-carboxylic-acid hydrazides. Biphenyl-4-carboxylic-acid hydrazides 1 on refluxing with aryl aldehydes in the presence of catalytic amount of glacial acetic acid furnish the biphenyl-4-carboxylic acid hyd...

rapid and highly efficient synthesis of 2- or 2,5-substituted 1,3,4-oxadiazoles by the condensation of aryl carboxylic acid hydrazides and orthoesters can be achieved under microwave irradiation using an unmodified commercial over in unsealed vessels.

A convenient and efficient method for the constructions of 3-spirooxindole derivatives or 3,3'-disubstituted oxindoles has been developed from one-pot reactions of isatins, hydrazides or aromatic amines, 2-(bromomethyl)acrylic ester and tin powder in the presence of a catalytic amount of Brønsted or Lewis acid. The method avoids the use of toxic stannanes and allows easy operation. It is also p...

Rapid and highly efficient synthesis of 2- or 2,5-substituted 1,3,4-oxadiazoles by the condensation of aryl carboxylic acid hydrazides and orthoesters can be achieved under microwave irradiation using an unmodified commercial over in unsealed vessels.

The coupling reaction of benzoic acid and nicotinic acid hydrazides with N- protected L-amino acids including valine, leucine, phenylalanine, glutamic acid and tyrosine is reported. The target compounds, N-Boc-amino acid-(N;-benzoyl)- and N- Boc-amino acid-(N;-nicotinoyl) hydrazides 5a-5e and 6a-6e were prepared in very high yields and purity using N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyr...