a new, high yielding method for the preparation of vasicinone (7) is described. reaction of 2-nitrobenzoic acid with n, n¢-carbonyldiimidazole followed by 2-pyrrolidinone gave 1-(2-nitrobenzoyl)pyrrolidine-2-one (3). reduction of the latter with 10% pd-c afforded deoxyvasicinone (4). reaction of deoxyvasicinone (4) with bromine yielded monobromo-deoxyvasicinone (5). exchange of bromine of 5 wit...

A new, high yielding method for the preparation of vasicinone (7) is described. Reaction of 2-nitrobenzoic acid with N, N¢-carbonyldiimidazole followed by 2-pyrrolidinone gave 1-(2-nitrobenzoyl)pyrrolidine-2-one (3). Reduction of the latter with 10% Pd-C afforded deoxyvasicinone (4). Reaction of deoxyvasicinone (4) with bromine yielded monobromo-deoxyvasicinone (5). Exchange of bro...