Central cholinergic system is involved in regulation of memory and disturbances in these results in memory loss. Previously, we examined the effect of okadaic acid, OKA (200ng, i.c.v.) on memory impairment and mitochondrial dysfunction in rats. In the present study, we investigated effect of OKA (i.c.v) on cholinergic function by observing acetylcholine level (ACh), acetylcholinestrase (AChE) a...

Imidacloprid insecticide was selected to study its effects on biochemical (total protein, acetylcholinestrase and nucleic acids) and histological (liver) parameters in female albino mice at orally administered doses of 25, 50 and 75% LD50 Imidacloprid and 40 mg/kg bw Cyclophosphamide (CP) and distilled water (DW). Significant decrease in total protein (P<0.01), acetylcholinestrase (P<0.001) and...

the effects of zinc and mercury on human erythrocyte acetylcholinestrase activity were studied. blood used in this study was obtained from 24 apparently healthy individuals and after hemolysation, was treted with 3 diferent concentrations of zinc and mercury. significant suppressions in acetylcholinestrase activity were recorded in treated samples by zinc and mercury. when compared to controls ...

objective(s):the present study was undertaken to determine the effects of acute exposure to malathion on oxidative stress and cytotoxic potential of anticholinesterase insecticide, malathion in reproductive toxicology of adolescent male mice. materials and methods: thirty two adolescent male mice at pubertal age were treated with 500 mg/kg body weight (bw) of malathion for three days. after exp...

Organophosphate (OPs) compounds are widely used in intensive agriculture to improve production, protect crops and control diseases vectors. The main mechanism of toxicity of OPs is the inhibition of the Cholinesterase enzymes. In this study the acetylcholinestrase (AChE), butyrylcholinesterase (BChE) and specific acetylcholinestrase (SAChE) activities as potential biomarkers of exposure to OPs ...

Article history: Received on: 11/10/2013 Revised on: 07/12/2013 Accepted on: 22/12/2013 Available online: 30/12/2013 Ethanolic extracts of three medicinal plants collected from South India were analyzed for their activity towards acetylcholinestrase (AChE) enzyme. The AChE inhibition was measured spectrophotometrically. All the three species namely, Baliospermum montanum, Humboldtia brunonis Wa...

organophosphate (ops) compounds are widely used in intensive agriculture to improve production, protect crops and control diseases vectors. the main mechanism of toxicity of ops is the inhibition of the cholinesterase enzymes. in this study the acetylcholinestrase (ache), butyrylcholinesterase (bche) and specific acetylcholinestrase (sache) activities as potential biomarkers of exposure to ops ...

Ricin is one of the most known toxic materials of plant origin. The 2007 Guinness World Records Book considers ricin the world's most potent plant toxin. It also possesses wide-ranging biological effects on higher organisms and it is a powerful inhibitor of cellular protein synthesis. Ricin is frequently therapeutically used in the construction of immunotoxins designed to kill specific target c...

Leutea avicenniae Mozaff. belongs to Apiaceae family is an endemic species distributed in the west of Iran. The aim of this study was to investigate the antioxidant activity and acetylcholinestrase (AchE) inhibition of the crude extract, fractions and isolated compounds from methanolic fraction of L. avicenniae. Five compounds were detected from methanol fraction, three phenolic compounds as p-...