b-biotype bemisia tabaci is a severe insect pest worldwide in many ornamental, agricultural, and horticultural crops. control of this insect is obstructed by resistance to many acetylcholinesterase (ache)-inhibiting insecticides, such as organophosphates and carbamates. in the present work, we evaluated the acetylcholinesterase inhibitory activity of six monoterpenoids namely α-pinene, terpineo...

background and objectives: alzheimer's disease (ad) is an age dependent disorder. ad is associated with decrease of brain acetylcholine level. nowadays, one of the methods for progression inhibition of ad is using acetylcholinesterase inhibitors. rosaceae is a large plant family. different biological effects of some species of this family have been reported. the aim of the present study was to ...

(E)-2-(benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles are described as a new class of selective inhibitors of acetylcholinesterase (AChE). The most potent compound in the series exhibited good AChE inhibitory activity (IC₅₀ = 64 µM). Compound 7f was found to be more selective than galanthamine in inhibiting AChE and it showed a moderate selectivity index. Kinetic studies on AChE indicated tha...

Acetylcholinesterase (AChE), hydrolyzes acetylcholine to choline and acetate, thereby terminating this neurotransmitter effect at cholinergic synapses. Therefore, AChE inhibition is used for counterbalance the deficit in Alzheimer’s disease (AD) patients. In present work, order find new plant acetylcholinesterase inhibitors, hydroalcoholic extracts from seventeen medicinal species were screened...

Organophosphorus and carbamate insecticides are toxic to insects and mammals by virtue of their ability to inactivate the enzyme acetylcholinesterase. This review addresses the mechanism of inhibition of acetylcholinesterase by organophosphorus and carbamate esters, focusing on structural requirements necessary for anticholinesterase activity. The inhibition of acetylcholinesterase by these com...

background and objectives:alzheimer’s disease (ad) is a neurodegenerative disorder. nowadays, many investigations are performed to find new drugs for ad and medicinal plants are considered as one of the most important sources for developing new drugs. according to the role of oxidant agents and acetylcholinesterase enzyme (ache) in ad, plants with antioxidant and ache inhibition properties coul...

Alzheimer's Disease (AD) is one of the consequences impaired functioning acetylcholine which can be hydrolyzed by enzyme acetylcholinesterase. treatment carried out using two approaches, namely compounds (acetylcholinesterase inhibitors) and noncholinergics (antioxidants). There are commercial drugs that slow progression Alzheimer's, but their use cause excessive side effects. The herbal plants...