objective(s): alzheimer's disease (ad) is a neurodegenerative disorder in elderly patients. decrease in cholinergic neurotransmission is the main known cause in the pathophysiology of the disease. improvement and potentiation of the cholinergic system could be beneficial for treatment of the ad. acetylcholinesterase inhibitors such as donepezil can enhance the duration of action of acetylc...

patients with alzheimer's disease have cognitive deficits, impaired long-term potentiation and learning and memory. a progressive reduction in cholinergic neurons in some areas of the brain such as cortex and hippocampus is related to the deficits in memory and cognitive function in alzheimer’s disease (ad). in the current project a new series of phthalimide derivatives were synthesized. p...

objective(s): alzheimer’s disease (ad) as progressive cognitive decline and the most common form of dementia is due to degeneration of the cholinergic neurons in the brain. therefore, administration of the acetylcholinesterase (ache) inhibitors such as donepezil is the first choice for treatment of the ad. in the present study, we focused on the synthesis and anti-cholinesterase evaluation of n...

Objective: Brain acetylcholinesterase activity was determined in healthy controls and in patients with mild cognitive impairment and early Alzheimer’s disease. Methods: A specific acetylcholinesterase tracer, [methylC]N-methyl-piperidyl-4-acetate ([C]MP4A), and a three dimensional PET system with magnetic resonance coregistration were used for imaging. Results: There was a significant differenc...

Acetylcholinesterase is an enzyme responsible for termination of excitatory transmission at cholinergic synapses by the hydrolyzing of a neurotransmitter acetylcholine. Nowadays, other functions of acetylcholinesterase in the organism are considered, for example its role in regulation of apoptosis. Cholinergic nervous system as well as acetylcholinesterase activity is closely related to pathoge...

background and objective: alzheimer’s disease (ad) is a multifactorial disease with debilitating consequences and few therapeutic strategies exist for it. with regard to antioxidant capacity and anti-β-amyloid polymerization potential of ellagic acid, this study was conducted to evaluate the effect of this substance on enhanced acetylcholinesterase reactivity in an experimental model of alzheim...

Alzheimer disease is the most common form of dementia, affecting nearly one-half [corrected] of Americans older than 85 years. It is characterized by progressive memory loss and cognitive decline. Amyloid plaque accumulation, neurofibrillary tau tangles, and depletion of acetylcholine are among the pathologic manifestations of Alzheimer disease. Although there are no proven modalities for preve...

background and objectives: alzheimer's disease (ad) is an age dependent disorder. ad is associated with decrease of brain acetylcholine level. nowadays, one of the methods for progression inhibition of ad is using acetylcholinesterase inhibitors. rosaceae is a large plant family. different biological effects of some species of this family have been reported. the aim of the present study was to ...

alzheimer is an age-dependent disease mostly with genetic origin. in this disorder, acetylcholine is decreased which results in deterioration of short-term memory. many researches have been focused on finding new sources of medications with more potency and less side effects and investigating acetylcholinesterase inhibitors (acheis) has been the center of many researches. in the present study, ...