The present study determines the efficacy of N-acetyl cysteine (NAC) on marker enzymes, lipid peroxidation and antioxidants in carbon tetrachloride induced hepatotoxicity in rats. Carbon tetrachloride (CCl4) (3 mL/kg/week) administered subcutaneously to albino Wistar rats for a period of three months significantly increased the activities of marker enzymes in plasma such as aspartate transamina...

amodiaquine is an antimalarial drug used in the prophylaxis and treatment of this disease. however, hepatotoxicity as a life‑threatening adverse effect is associated with its clinical use. we evaluated amodiaquine-induced toxicity in isolated rat hepatocytes as an in vitro model for studying drug‑induced hepatotoxicity. this study attempts to investigate the protective effects of taurine and n-...

background acute pancreatitis is the most common serious complication of endoscopic retrograde cholangiopancreatography (ercp) that can occasionally be fatal. multiple drugs have been examined for the prevention of this side effect, with generally uncertain results. this study is an effort to prevent this complication by the use of oral n-acetyl cysteine (nac). methods a total of 100 patients w...

laryngopharyngeal reflux (lpr) is a variant of gastroesophageal reflux disease (gerd) in which the stomach contents go up into the pharynx and then down into the larynx. lpr causes a wide spectrum of manifestations mainly related to the upper and the lower respiratory system such as laryngitis, asthma, chronic obstructive pulmonary disease, cough, hoarseness, postnasal drip disease, sinusitis, ...

conclusions the effect of coadministration of nac and coq10 was neither additive nor synergic in protecting against nihl. results the temporary hearing changes that occurred 1-day post exposure were not significantly different in all groups (p > 0.05). the total recovery (between 1 - 21 days after noise exposure) varied by a frequency increase between 1.08 - 19.10 in the noise group compared to...

OBJECTIVE This study was performed to determine the effect of N-acetyl-L-cysteine, a modified sulfur-containing amino acid that acts as a strong cellular antioxidant, on the response to environmental stressors and on aging in C. elegans. METHOD The survival of worms under oxidative stress conditions induced by paraquat was evaluated with and without in vivo N-acetyl-L-cysteine treatment. The ...

The effect of Vitamin E and N-acetyl cysteine on oxidative status hemoglobin level in transfusion-dependent thalassemia patients: A systematic review meta-analysis

N-acetyl-L-cysteine is known to act as a reactive oxygen species scavenger and used in clinical applications. Previous reports have shown that high-dose N-acetyl-L-cysteine treatment inhibits the expression of proinflammatory cytokines in activated macrophages. Here, we have found that long-time N-acetyl-L-cysteine treatment at low-concentration increases phosphorylation of extracellular signal...

background: sodium arsenite (naaso2) has potent cytotoxic activity in human cancer cells. oxidative stress has been suggested as a mechanism for arsenic-induced carcinogenesis. the purpose of the present study was to evaluate the alteration of mrna levels of catalase ( cat ) and superoxide dismutase 2 ( sod2 ) in mcf-7 and jurkat cells after exposure to naaso 2 . methods: methylthiazol tetrazol...