نتایج جستجو برای: Acetaminophen (APAP)

تعداد نتایج: 10506  

2011
Kennon J Heard Jody L Green Laura P James Bryan S Judge Liza Zolot Sean Rhyee Richard C Dart

BACKGROUND Acetaminophen-cysteine adducts (APAP-CYS) are a specific biomarker of acetaminophen exposure. APAP-CYS concentrations have been described in the setting of acute overdose, and a concentration >1.1 nmol/ml has been suggested as a marker of hepatic injury from acetaminophen overdose in patients with an ALT >1000 IU/L. However, the concentrations of APAP-CYS during therapeutic dosing, i...

Journal: :Yeni üroloji dergisi 2023

Objective: Montelukast, an asthma drug, has anti-inflammatory effect on tissues. We aimed to investigate therapeutic of montelukast (MK) acetaminophen (APAP) - induced renal damage in rat models. Material and Methods: Twenty-four rats were randomly divided into four groups six animals each. APAP was administered intraperitoneally as a single dose 1000 mg/kg/day. In the treatment group, MK 10 mg...

2013
Parth J. Parekh Thomas J. Manser

Patients presenting with elevated transaminases and jaundice are routinely tested for viral, autoimmune and drug etiologies. Acetaminophen (APAP) toxicity is a common and treatable cause of toxic hepatitis and elevated APAP levels in the setting of acute liver injury usually imply that acetaminophen is a primary contributor to the injury. Rare case reports, however, have described elevated leve...

2017
Robin H. Schmidt

SULFORAPHANE PREVENTS ACETAMINOPHEN-INDUCED HEPATIC INJURY IN MICE Robin H. Schmidt 11/29/2011 Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, is known to confer antioxidant protection in vivo. Rather than directly reacting with free radicals, however, SFN works by inducing Nrf2, a transcription factor that binds to the promoter regions of several known antioxidant genes ...

Ramin Pashazadeh‎, Abdolamir ‎ Allameh, Bahram Daraei, Kamran Moradi Peynevandi, Seyed Ali Hashemi,

Background: Acetaminophen (APAP) overdose causes renal and hepatic injury. It is ‎also believed that oxidative stress has a pivotal role in APAP-induced renal injury. ‎Therefore, protective effects of different antioxidants have been examined in APAP-‎induced renal and hepatic toxicity models. Stevia rebadiana is a plant with a high ‎degree of natural antioxidant activity in its leaf extract. T...

Journal: :Nigerian Journal of Biotechnology 2023

Acetaminophen commonly referred to as paracetamol is an analgesic and antipyretic drug available over the counter medications. Indiscriminate use of acetaminophen for management pain fever causes liver damage. The study evaluated hepatoprotective effect Laportea aestuans aqueous leaf extract in acetaminophen-treated mice. Group 1: control, 2: APAP treated, 3, 4, 5, 6 7 received 25, 50, 100, 200...

Journal: :Journal of clinical gastroenterology 2015
Edward W Holt Sara DeMartini Timothy J Davern

GOALS To identify an association between prior weight loss surgery (WLS) and acetaminophen-induced acute liver failure (ALF). BACKGROUND WLS, which has increased in proportion to the global rise of obesity, alters the absorption and metabolism of many drugs including acetaminophen (APAP) and may predispose to toxicity. No study has identified an association between prior WLS and APAP-ALF. S...

Journal: :Jundishapur Journal of Natural Pharmaceutical Products 2021

Background: Acetaminophen (APAP) is a common analgesic and antipyretic medicine that can lead to acute liver injury at high doses. Crocin, Crocus sativus’ ingredient, has potent antioxidant effects. Objectives: This study examined the protective effects of crocin against APAP-induced oxidative stress in mice. Methods: In this study, 56 mice were randomly divided into seven groups (n = 8 per gro...

2015
A. D. B. Vliegenthart J. M. Shaffer J. I. Clarke L. E. J. Peeters A. Caporali D. N. Bateman D. M. Wood P. I. Dargan D. G. Craig J. K. Moore A. I. Thompson N. C. Henderson D. J. Webb J. Sharkey D. J. Antoine B. K. Park M. A. Bailey E. Lader K. J. Simpson J. W. Dear

Our objective was to identify microRNA (miRNA) biomarkers of drug-induced liver and kidney injury by profiling the circulating miRNome in patients with acetaminophen overdose. Plasma miRNAs were quantified in age- and sex-matched overdose patients with (N = 27) and without (N = 27) organ injury (APAP-TOX and APAP-no TOX, respectively). Classifier miRNAs were tested in a separate cohort (N = 81)...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2003
Kartik Shankar Vishal S Vaidya Udayan M Apte Jose E Manautou Martin J J Ronis Thomas J Bucci Harihara M Mehendale

Streptozotocin (STZ)-induced diabetic (DB) mice challenged with single ordinarily lethal doses of acetaminophen (APAP), carbon tetrachloride (CCl4), or bromobenzene (BB) were resistant to all three hepatotoxicants. Mechanisms of protection against APAP hepatotoxicity were investigated. Plasma alanine aminotransferase, aspartate aminotransferase, and liver histopathology revealed significantly l...

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