The free-living amoeba (FLA) group of protozoa that can be found in various types conditions nature, one which is the genus Acanthamoeba. Although, number infections caused by this protozoan low, diagnosis was still difficult to confirm and therefore there were a higher mortality, especially those associated with encephalitis. This review presents some information about biology, pathogenesis, c...

acanthamoeba keratitis (ak) is a sight-threating infection of the cornea that mostly affects contact lens wearers. until now, ak treatment remains very difficult due to the existence of a highly resistant cyst stage in the life cycle of acanthamoeba which is extremely resistant to most of the available anti-amoebic compounds. moreover, current treatment of ak is usually based in the combination...

Infections of the corneal surface are an important cause of blindness. Protozoal, viral, bacterial, and helminthic infections of the cornea account for up to 9 million cases of corneal blindness. Free-living amoebae of the genus Acanthamoeba produce a progressive infection of the cornea called Acanthamoeba keratitis. Disease is usually transmitted by Acanthamoeba trophozoites bound to soft cont...

background: acanthamoeba spp. is the causative agent of blindness keratitis and fatal encephalaitis. presence of acanthamoeba spp. in a wide variety of niches such as different water types can lead to exposure of high risk people such as contact lens wearers. the main aim of the present study was to explore the occurrence of acanthamoeba genotypes in the recreational water sources using both mo...

We examined partial 18S ribosomal DNA (Rns) sequences of Acanthamoeba isolates cultured in a study of microbial keratitis in Hong Kong. Sequence differences were sufficient to distinguish closely related strains and were used to examine links between strains obtained from corneal scrape specimens, contact lenses, lens cases, lens case solutions, and home water-supply faucets of patients with Ac...

Acanthamoeba is a protozoan pathogen that is responsible for two recognized diseases; i) a blinding keratitis, most commonly associated with contact lens wear, and ii) a rare but fatal granulomatous encephalitis that usually is limited to immunocompromised patients. The fact that Acanthamoeba infections are generally limited to avascular cornea or immunocompromised patients suggests that the no...

Acanthamoeba is an opportunistic protozoan that is widely distributed in the environment and is well recognized to produce serious human infections, including a blinding keratitis and a fatal encephalitis. This review presents our current understanding of the burden of Acanthamoeba infections on human health, their pathogenesis and pathophysiology, and molecular mechanisms associated with the d...

background: the free-living amoebae acanthamoeba spp. have been recognized as etiologic agents of amoebic encephalitis, keratitis, otitis, lung lesions and other skin infections mainly in immuno-compromised individuals. the purpose of this study is to detect the presence of acanthamoeba in swimming pools in egypt using a polymerase chain reaction (pcr) method. methods: water samples were collec...

For a more precise definition of the clinicopathological features of experimental acanthamoebic infection in mice, trophozoites of Acanthamoeba castellanii and Acanthamoeba polyphaga were instilled intranasally into adult white mice. Eight to 20 days after inoculation, severe pulmonary disease developed; one to two days later, neurological signs ensued. On pathologic examination an amebic bronc...