نتایج جستجو برای: ATC-40
تعداد نتایج: 334885 فیلتر نتایج به سال:
Investigated in this paper is the approximation in the ATC-40 nonlinear static procedure (NSP) that the earthquake-induced deformation of an inelastic single-degree-of-freedom (SDF) system can be estimated by an iterative method requiring analysis of a sequence of equivalent linear systems. Several deficiencies in the ATC-40 Procedure A are demonstrated. This iterative procedure did not converg...
Anaplastic thyroid carcinoma (ATC) remains one of the most lethal human cancers. We hypothesized that sorafenib, a multikinase inhibitor of the BRaf, vascular endothelial growth factor receptor-2, and platelet-derived growth factor receptor-beta kinase, would decrease tumor growth and angiogenesis in an orthotopic model of ATC. The in vitro antiproliferative and proapoptotic effects of sorafeni...
Overexpression of the receptor tyrosine kinase HER-2/neu is associated with poor prognosis in patients with breast and ovarian cancer. Recent excitement has surrounded the therapeutic effects of HER-2-blocking therapy strategies and has rekindled interest on the molecular mechanisms of HER-2/neu in tumor biology. To study the role of HER-2/neu overexpression in vivo, we used a murine fibroblast...
The phosphatidylinositol 3'-kinase (PI3K) pathway is frequently activated in thyroid carcinomas through the constitutive activation of stimulatory molecules (e.g., Ras) and/or the loss of expression and/or function of the inhibitory PTEN protein that results in Akt activation. Recently, it has been reported that somatic mutations within the PI3K catalytic subunit, PIK3CA, are common (25-40%) am...
Background Anaplastic thyroid cancer (ATC) is a rare but extremely aggressive cancer of the thyroid, contributing up to 30-40% of thyroid cancer-specific mortality. We analyzed ATC characteristics and survival rates in Sicily to evaluate the possible influence of environmental factors. With this aim, data regarding ATC incidences in urban/rural and industrial, iodine-deficient, and volcanic vs ...
introduction: acute traumatic coagulopathy (atc) is defined as having evidence of coagulopathy in patients with severe trauma. the aim of this preliminary study was to assess the prevalence and associated factors of atc in severely traumatic patients presenting to emergency department (ed). methods: in this retrospective cross sectional study, all patients with severe traumatic injury and avail...
BACKGROUND Anaplastic thyroid cancer (ATC) is an aggressive malignant tumour with a poor prognosis. The median overall survival is described in the literature to be just 6 months, however, in series of selected patients treated by multimodal therapy cases of long-time-survival have been reported. We analyzed the role of radiotherapy and the impact of other therapies and clinical features on sur...
Analisis kinerja struktur merupakan metode analisis pasca elastis yang mana bertujuan untuk mendapatkan besarnya gaya geser dasar dan perpindahan maksimum pada bangunan. Pada paper ini ditampilkan hasil evaluasi gedung telah dibangun dengan sistem rangka terbuka berfungsi sebagai rumah susun empat tingkat didesain berlokasi di Malang, Jawa Timur. Gedung beban gempa berdasarkan respon spektrum d...
BACKGROUND Acute traumatic coagulopathy (ATC) has been linked to an increase in activated protein C (aPC) from 40 pM in healthy individuals to 175 pM. aPC exerts its activity primarily through cleavage of active coagulation factor Va (fVa). Platelets reportedly possess fVa which is more resistant to aPC cleavage than plasma fVa; this work examines the hypothesis that normal platelets are suffic...
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