In vitro experiments have related anaphylactoid reactions in patients treated with angiotensin-converting enzyme (ACE) inhibitors during dialysis with AN69 membranes to excessive bradykinin generation using this negatively charged dialysis membrane. In the present clinical trial plasma bradykinin levels were followed during the early phase of dialysis in 10 patients, not being treated with ACE ...

BACKGROUND AN69 dialyzer, a plate type dialyzer with a polyacrylonitrile membrane (PAN membrane) is reported to reduce symptoms in hemodialysis (HD) patients with complications such as poor nutritional status and peripheral arterial disease (PAD). Yet very few studies have investigated the long-term use of the PAN membrane or compared the solute-removal properties of the PAN membrane with those...

Anaphylactoid reactions (AR) are the most feared complications of hemodialysis. Recently, a high incidence of AR has been reported during dialysis with AN69 membranes in patients treated with ACE inhibitors. Plasma levels of C3a, histamine and bradykinin were measured in 12 patients at the onset of AR during dialysis with AN69. We also investigated bradykinin generation in 10 symptom-free patie...

Sir, AN69-associated reactions in haemodialysed patients receiving angiotensin-converting enzyme inhibitors (ACEI) are well-documented [1]. The negatively charged AN69 membrane is thought to activate the bradykinin system. Moreover, ACEI reduces bradykinin inactivation. Surface-treated AN69 is considered to be safer in that regard. To our knowledge, only one case of anaphylactoid reaction induc...

Acute reactions to the haemodialysis membrane have been reported as early as 1975 [1]. Because their severity is usually mild, their frequency is probably widely underestimated. However, these reactions may occasionally be life-threatening [2]. The aetiological mechanisms of these reactions are multiple, the best characterized being allergy to ethylene oxide and combined exposure to the polyacr...

BACKGROUND Critically ill patients requiring renal replacement therapy (RRT) are at risk of disease-related bleeding. Systemic heparinization should be avoided. AN69ST, a polyethyleneimine-treated polyacrylonitrile (AN69) membrane hemofilter, can be primed with heparin, improving its local anticoagulative activity. Prolonged intermittent RRT (PI-RRT) is of shorter duration and cheaper, consider...

AN69 membrane is not suited for diffusion, with an suggested limit at 25 mL/min dialysate flow rate. When prescribing continuous hemodialysis this threshold must be surpassed to achieve. We designed a study aimed to check if a higher dose of dialysis could be delivered efficiently with this membrane. Ten ICU patients under continuous hemodiafiltration with 1.4 m(2) AN69 membrane were included a...

Hemodialysis is frequently complicated by hypotension and associated symptoms. It has been suggested that these symptoms may be related to the biochemical changes caused by cellulosic dialysis membranes. In this study, a prospective randomized crossover trial was conducted comparing the incidence of hypotension and acute symptoms during dialysis with large-surface-area (1.6 m2) cellulosic (cupr...

PURPOSE To search for methods of improving the excretion of injected gadolinium contrast medium (GdCM) in hemodialysis (HD) patients, we investigated the effect of the surface potential of HD membranes and the electrical charge of GdCM on the dialyzability of GdCM. MATERIALS AND METHODS Ionic (Gd-DTPA) or non-ionic (Gd-DO3A) GdCM solutions were dialyzed using a clinical HD unit. Two types of ...

The handling of low, middle and high molecular weight markers was examined in seven stable dialysis patients during hemofiltration with different membranes. Four membranes were examined in a randomized, crossover order (polysulfone, polyamide, AN69 polyacrylonitrile, Asahi polyacrylonitrile) by measuring plasma and dialysate concentrations of phosphate, creatinine, vitamin B12, beta 2-microglob...