نتایج جستجو برای: AMPK pathway
تعداد نتایج: 319504 فیلتر نتایج به سال:
Objective(s): AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models. The aim of this study was to evaluate the effect of AMPK/SIRT1 pathway on autophagy after spinal cord injury (SCI). Materials and Methods:The SCI model was established in rats in vivo and the primary spinal cord neurons were subject...
Introduction: Blood glucose is high in diabetic patients. It is taken from blood by two separate pathways: Insulin-dependent pathway of phosphoinositide 3 kinase (PI3K) and insulin-independent pathway AMPK (AMP-Activated protein kinase). The first pathway is impaired in type 2 diabetic patients, but the second pathway is active. On the other hand, curcuma longa extract containing a high percent...
Introduction: AMP activated protein kinase (AMPK) as key regulators of cell metabolism, plays a major role in the activation of catabolic pathways, such as glucose transport and fatty acid oxidation. Thus, activation of this pathway can be used in the treatment of diabetes and metabolic syndrome. Many studied proposed the effectiveness of the polyphenols present in rhizomes of turmeric (curcumi...
Background: One of the most important biological pathways involved in maintaining energy homeostasis is the AMPK PGC-1α pathway. Activation of this pathway through exercise can be important in regulating mitochondrial biogenesis processes and maintaining energy balance in diabetics. Therefore, the aim of this study was to investigate the effect of endurance exercise on the content of AMPK and P...
atherosclerosis has serious role in coronary arteries disease,so it is important to establish effective strategies for prevention or even treatment of atherosclerosis. adiponectin, as one of the most abundant adipokines, has insulin sensitivity, anti-inflammatory and anti-atherogenic properties. disturbed adiponectin actions through its receptor, (adipor1 and adipor2) may be involved in atheros...
The aim of the paper is to explore whether AMPK/UlK1 signaling pathway involved in regulating autophagy and alleviating cerebral ischemia/reperfusion (I/R) injury. On this basis, study regulatory effect Buyang Huanwu Decoction (BHD) on pathway, aiming clarify molecular mechanism BHD I/R injury protective containing serum (BHDS) OGD/R neurons. research group adopted following methods: Neurons cu...
Atherosclerosis has serious role in coronary arteries disease,so it is important to establish effective strategies for prevention or even treatment of atherosclerosis. Adiponectin, as one of the most abundant adipokines, has insulin sensitivity, anti-inflammatory and anti-atherogenic properties. Disturbed adiponectin actions through its receptor, (AdipoR1 and AdipoR2) may be involved in atheros...
This study discusses the construction of mathematical models for mechanism protein synthesis involving main regulator mTORC1 gene which is described in singular pathway mTOR AMPK pathway. The genes question include: AMPK, TSC2, Rheb, and S6K. method used this research divided into two stages, namely analysis second formulation models. Pathway performed as a reference describing interactions for...
Zingerone possesses the potential to relieve asthma via upregulating AMPK/Nrf2/HO-1 signaling pathway.
Abstract Background Metabolic dysregulation is one of the hallmarks tumor cell proliferation. Evidence indicates potential role 5′adenosine monophosphate-activated protein kinase (AMPK) and B/Akt signaling pathway in regulating proliferation, survival, apoptosis. The present study explores effect metformin HCl combination α- β-asarone on proliferation HepG2 cells presence high glucose levels si...
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