We previously reported that accessory sex gland fluid (AGF) from high fertility (HF) bulls influenced the oocyte-penetrating capacity of cauda epididymal sperm from low fertility (LF) bulls, based on in vitro fertilization (IVF) assays. The present study determined if AGF proteins were associated with these effects. Nineteen IVF assays with 12 bulls were grouped as follows. Group I (n1⁄48): ass...

We report here the identification of angiopoietin-related growth factor (AGF) as a positive mediator for angiogenesis. To investigate the biologic function of AGF in angiogenesis, we analyzed the vasculature in the dermis of transgenic mice expressing AGF in mouse epidermal keratinocytes (K14-AGF). K14-AGF transgenic mice were grossly red, especially in the ears and snout, suggesting that hyper...

We report here the identification of angiopoietin-related growth factor (AGF) as a positive mediator for angiogenesis. To investigate the biologic function of AGF in angiogenesis, we analyzed the vasculature in the dermis of transgenic mice expressing AGF in mouse epidermal keratinocytes (K14-AGF). K14-AGF transgenic mice were grossly red, especially in the ears and snout, suggesting that hyper...

We report here the identification of an angiopoietin-related growth factor (AGF). To examine the biological function of AGF in vivo, we created transgenic mice expressing AGF in epidermal keratinocytes (K14-AGF). K14-AGF mice exhibited swollen and reddish ears, nose and eyelids. Histological analyses of K14-AGF mice revealed significantly thickened epidermis and a marked increase in proliferati...

OBJECTIVE Transgenic mice overexpressing angiopoietin-related growth factor (AGF) exhibit enhanced angiogenesis, suggesting that AGF may be a useful drug target in ischemic disease. Our goal was to determine whether AGF enhances blood flow in a mouse hind-limb ischemia model and to define molecular mechanisms underlying AGF signaling in endothelial cells. METHODS AND RESULTS Intramuscular inj...

Airway gastric fistula (AGF) is a rare but dangerous complication following esophagectomy for esophageal cancer, with an incidence rate of 0.3–1.9%.[1] For AGF, the primary goal is closure of the fistula between the digestive and respiratory tracts to avert ongoing soilage of the airway. Although surgical repair remains the definitive treatment, it is associated with a mortality rate of 32%.[2]...

Department of Internal Medicine (AMLL), & Dept. of Anesthesia (RM, GW), Addenbrooke’s Hospital, University of Cambridge, Cambridge, UK Dept. of Chemistry (CA, MF), University of Cambridge, Cambridge, UK SynGenix LTD, Cambridge, UK (AGF, GW, MB, MF) Museum of Comparative Zoology and Department of Anthropology, Harvard University, Cambridge, MA (AGF, TWD, MKR, AJS) Dept. of Neurosurgery, Atkinson...

INTRODUCTION AND OBJECTIVE Acute graft failure (AGF) is defined as significant failure of myocardial function in a newly implanted heart. The aim of the present study was to investigate a series of factors related to heart transplantation (HT) in relation to AGF. MATERIAL AND METHOD In a study of 287 consecutive HTs performed over a 14-year period, AGF was defined when: a) the surgeon observe...

BACKGROUND Preeclampsia is a serious complication in pregnancy with an increased future cardiovascular and metabolic risk for both mother and newborn. Recently, angiopoietin-related growth factor (AGF) was introduced as a novel liver-derived protein with proangiogenic and insulin-sensitizing effects. In the current study, we hypothesized that serum levels of AGF would be lower in preeclamptic p...

BACKGROUND Diamine silver fluoride (Ag(NH3)2F), referred to as AgF, has been used to reduce the incidence of caries in primary dentitions but has been limited by the associated staining of both teeth and restorative materials. The application of potassium iodide (KI), following AgF prevents staining but its effects on the ability of AgF to reduce caries are not known. The aim of this study was ...