The concept of average degree-eccentricity matrix ADE(G) of a connected graph $G$ is introduced. Some coefficients of the characteristic polynomial of ADE(G) are obtained, as well as a bound for the eigenvalues of ADE(G). We also introduce the average degree-eccentricity graph energy and establish bounds for it.

One of the main problems arising in the field of the health is the Adverse Drug Event (ADE). The computer system which aimed to prevent the ADE lacks the ADE knowledge standardization. So the background ADE knowledge is needed. This study presents ADE ontology of diabetes disease which includes the terms relative to the diabetes ADE. Our goal is to organize and structure the information relativ...

BACKGROUND Patients with heart failure (HF) often perceive adverse drug events (ADEs), affecting quality of life. For weighing the benefits and burden of medication in HF care, knowledge on patients' perception of ADEs is needed. Our aim was to assess these ADE perceptions and to identify factors related to these perceptions. METHODS A cross-sectional study was performed including HF patients...

Adverse drugs events (ADEs) detection constitutes a considerable concern in patient safety and public health care. For this reason, it is important to develop methods that improve ADE signal detection in pharmacovigilance databases. Our objective is to apply 3D pharmacophoric similarity models to enhance ADE recognition in Offsides, a pharmacovigilance resource with drug-ADE associations extrac...

Adenosine (Ade) is an antiepileptic agent. In order to investigate the possible mechanism of action of Ade, its effect on calcium (Ca2+) oscillations in hippocampal neurons of Sprague Dawley (SD) rats was explored. Primary hippocampal neurons were cultured from suckling neonatal SD rats. Cells were cultured for 7-9 days and the Ca2+ oscillations in response to perfusion with Ade were detected u...

BACKGROUND Previous studies of adverse drug events (ADE) as a cause of hospital admission in the elderly have often been limited in their ability to assess fully the impact and potential for prevention because they either did not include all categories of ADE and/or did not assess severity and preventability. AIMS To assess the frequency, severity and preventability of ADE causing emergency m...

OBJECTIVE To assess the frequency of adverse drug event (ADE)-related admissions (ADE-RAs) during a prospective medical record review of patients admitted to a metropolitan tertiary referral hospital. METHODS Potential ADE-RA cases were identified by examination of case records of randomly selected patients. Cases were assessed by an expert panel to measure study outcomes, which were the freq...

This paper examines the interplay of the effect of cross immunity and antibody-dependent enhancement (ADE) in multistrain diseases. Motivated by dengue fever, we study a model for the spreading of epidemics in a population with multistrain interactions mediated by both partial temporary cross immunity and ADE. Although ADE models have previously been observed to cause chaotic outbreaks, we show...