Adrenal hormones, ACTH plasma concentrations and the ultrasonographic evaluation of adrenal glands are considered complementary in clinical evaluations hypothalamic–pituitary–adrenal (HPA) axis function several species. In dogs, age, size weight have a significant effect on glands. neonatal foals, measurements been demonstrated to be reliable; however, individual variables features has not inve...

     The goal of this study was to evaluate the effects of quercetin and ACTH injection on prevention of development of morphine tolerance and dependence in mice. In this study different groups of mice received morphine (40 mg/kg, i.p.) plus quercetin (5, 10, 25 mg/kg, ip), ACTH (1, 2.5, 5 IU/mice, i.p.), or combination of quercetin (5 mg/kg) and ACTH (1 IU/mice) once a day for four days. Toler...

Background Infantile spasm is a rare condition in infants from 4 to 7 months old. Treatment varies in different cases. Corticosteroids and adrenocorticotropic hormone (ACTH) are the most widely used treatment options; however, there are debates on their efficacy. The aim of our study is to compare corticosteroid treatment with ACTH in patients with infantile spasm. Materials and Me...

Multi-secreting pituitary adenomas are relatively rare. The mixed somatotropic and corticotropic adenoma is very most widely described association that coupling hypersecretion of GH prolactin. We report the case a patient with bi-secreting ACTH. He was 28-year-old admitted for tumor syndrome, cushing syndrome. hormonal assessment found dependent ACTH other hypothalamohypophysial axes were witho...

Introduction: Ghrelin is a peptide hormone secreted from the stomach with both endocrine and paracrine effects. Ghrelin and its mRNA as well as growth hormone (GH) secretagogue receptor mRNAs are expressed in the pancreas and islet cells and regulate insulin release. Also the immounoreactivity of ghrelin is proved to be high in the hypothalamus and parts of the brain responsible for the re...

The most common cause of adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome is a benign ACTH-producing pituitary tumour or, less frequently, ectopic ACTH production from non-pituitary tumours. Ectopic occurs more commonly in men and usually presents after 40 years. It associated with small cell lung cancer. Although this severe hypercortisolemia, some findings syndrome, such as cen...

Introduction Administration of dexamethasone (DEX) has been used experimentally to suppress androgenization external genitalia in 46,XX fetuses with congenital adrenal hyperplasia. Despite this, the prenatal biological mechanism-of-action DEX on fetal development is not known. This study aimed examine direct effects human (HFA) steroidogenic activity including possible subsequent response ACTH-...

Early embryonic development may be affected by adrenal hyperactivity in stressful situations which lead to endocrine changes the embryo environment. A sensitive period porcine is 4-cell stage when genome activation occurs. mixed vivo-in vitro system was implemented test whether an altered milieu around this could affect and blastocyst quality model. After maturation fertilisation, presumptive z...

Pure monoiodo ACTH-(125)I was prepared that was biologically active and free of unlabeled ACTH. Extracts of adrenal cortex that contained ACTH-sensitive adenyl cyclase, bound ACTH-(125)I; extracts that lacked the ACTH-sensitive cyclase did not bind ACTH-(125)I. Unlabeled ACTH inhibited the binding of ACTH-(125)I. Five ACTH derivatives which varied widely in biological activity were tested. All ...