Background: Photodynamic therapy (PDT) is a promising therapeutic modality for the treatment of cancer and other diseases. In this study, the epidermoid carcinoma cell line A431 and the normal fibroblasts were used to investigate whether gold nanoparticles (GNPs) can induce an increase in cell death during PDT using 5-aminolevulinic acid (5-ALA) as a photosensitizer.Methods: Human fibroblast an...

background: photodynamic therapy (pdt) is a promising therapeutic modality for the treatment of cancer and other diseases. in this study, the epidermoid carcinoma cell line a431 and the normal fibroblasts were used to investigate whether gold nanoparticles (gnps) can induce an increase in cell death during pdt using 5-aminolevulinic acid (5-ala) as a photosensitizer. methods: human fibroblast a...

A431 human epidermoid carcinoma cells monophenotypically express the placenta! alkaline phosphatase (PLAP)-like enzyme shown by its catalytic and antigenic characteristics, properties which are shared by the Nagao isozyme. More specifically, it is L-leucine sensitive just as is the rare placenta! D-variant of PLAP and the testicular heat-stable enzyme. Collectively, these are all referred to as...

This study aimed to synthesize chitosan/polyvinyl alcohol (CS/PVA)-based zinc oxide (ZnO) and titanium dioxide (TiO2) hybrid bionanocomposites (BNCs) observe their comparative accomplishment against the skin cancer cell line, A431, antioxidant potential. CS was blended with PVA form polymeric films reinforced immobilization of ZnO TiO2 nanoparticles (NPs), separately. The optimization BNCs done...

Calotropis gigantea (Linn) and Amoora rohituka (Roxb.) have long been used in folkloric medicine for the treatment of various ailments in Bangladesh. The present study was designed to investigate the cytotoxicity of isolated compounds from these two plants. Two compounds, named β-boswellic acid (compound-1) and 2-methoxy-14-calamenenone (compound-2) were isolated from the flowers of Calotropis ...

A431 human epidermoid carcinoma cells monophenotypically express the placental alkaline phosphatase (PLAP)-like enzyme shown by its catalytic and antigenic characteristics, properties which are shared by the Nagao isozyme. More specifically, it is L-leucine sensitive just as is the rare placental D-variant of PLAP and the testicular heat-stable enzyme. Collectively, these are all referred to as...

Monoclonal antibodies (MoAbs) were raised against epidermal growth factor (EGF) receptors on a human epidermoid carcinoma cell line, A431. Administration of anti-EGF receptor MoAbs inhibited tumor formation in athymic mice by A431 cells and by another epidermal carcinoma cell line, T222. When one of the same MoAbs was used in therapy against Li-7 (a human hepatoma) and HeLa cells (a cervical ca...

conclusions this study delineated the beneficial role of rsv for growth regulation of skin cancer cells and highlighted the involvement of rsv in the induction of apoptosis in a431 cells. these findings might conduct evidence into the oncolytic properties of rsv in the skin cancer. further studies are required to indicate intracellular targets for rsv-induced apoptosis in skin cancer cells. res...

In recent years, nanotechnology has gained serious attention for diagnosis, prevention and treatment roles. In this study we synthesized nanoceria or CeO2NPs (cerium oxide nanoparticles) and compared toxicity of cerium oxide powder in nano and bulk forms in two cancerous and one normal cell lines. The cell lines were cultured in a standard humidified incubator, at 37 °C in a 5% CO2 atmosphere, ...

Skin cancer is one of the primary causes of mortality worldwide. With an increasing frequency of skin cancers, there is an urgent requirement for the development of numerous treatment options. The present study investigated the anticancer activity of caffeic acid n‑butyl ester (CAE) against the A431 skin cancer cell line. Antiproliferative effects were investigated using an MMT assay. Apoptosis...