p53 protects cells from genetic assaults by triggering cell-cycle arrest and apoptosis. Inactivation of p53 pathway is found in the vast majority of human cancers often due to somatic missense mutations in TP53 or to an excessive degradation of the protein. Accordingly, reactivation of p53 appears as a quite promising pharmacological approach and, effectively, several attempts have been made in...

fle findings as far north as Gotland (a Baltic island off the southeast Swedish coast) further suggest a close link to environmental change (Wedén et al. 2005). Assessment of high-resolution climatic data (Mitchell and Jones 2005) revealed spatial differences of ~0.5 ̊C between mean temperatures in Burgundy and our study site, which corresponded with temporal changes in mean temperatures observe...

BACKGROUND Lithotomy (LT) and prone jackknife positions (PJ) are routinely used for abdominoperineal resection (APR). The present study compared the clinical, pathological, and oncological outcomes of PJ-APR vs. LT-APR in low rectal cancer patients in order to confirm which position will provide more benefits to patients undergoing APR. METHODS This is a retrospective study of consecutive pat...

PURPOSE This study compared the perioperative and pathologic outcomes between an extralevator abdominoperineal resection (APR) in the prone position and a conventional APR. METHODS Between September 2011 and March 2014, an extralevator APR in the prone position was performed on 13 patients with rectal cancer and a conventional APR on 26 such patients. Patients' demographics and perioperative ...

Inactivation of the Caenorhabditis elegans APC-related gene (apr-1) has pointed at two separate functions of apr-1. First, apr-1 is required for the migration of epithelial cells during morphogenesis of the embryo. In this process, APR-1 may act in a Cadherin/alpha-Catenin/beta-Catenin complex as a component of adherens junctions. Second, apr-1 is required for Hox gene expression, most likely b...

Feb-Mar Feb-Apr Mar Apr Apr-May Apr-Jun Apr Jun-Jul Aug Sep-Oct Oct-Nov Oct-Nov Nov-Dec Nov-Dec Dec Develop research proposal Research literature Identify most used resources Define client profiles Develop study process Invite and select participants Select resources for card sort Test and refine process Conduct study with thirty participants Analyze data Finalize home page design Release beta ...

Sulfur-containing compounds play an important role in plant stress defense; however, only a little is known about the molecular mechanisms of regulation of sulfate assimilation by stress. Using known Arabidopsis (Arabidopsis thaliana) mutants in signaling pathways, we analyzed regulation of the key enzyme of sulfate assimilation, adenosine 5'-phosphosulfate reductase (APR), by salt stress. APR ...