BACKGROUND The reliable method for determination of identity and radiochemical purity (RCP) is of great importance in radiopharmaceutical development. This is especially relevant when more than one form of radiometal/ligand complex can be formed during radiolabelling, such as complexes of 99mTc or 188Re with meso-2,3-dimercaptosuccinic acid (DMSA), where depending on the pH, metal can occur eit...

This study compares the accuracy of 99mTc(V)-dimercaptosuccinic acid (99mTc(V)-DMSA) Single Photon Emission Computer Tomography (SPECT) by intravenous or local injection in the detection of occult cervical lymph node metastases in clinically N0 squamous cell carcinoma of the oral cavity. Fifty-eight previously untreated patients without clinically detectable cervical metastases were included in...

OBJECTIVE The aim of this study was to compare the renal function measured with either 99mTc-DTPA or 99mTc-EC dynamic scintigraphies with that measured using 99mTc-DMSA static scintigraphy. METHODS the values of relative renal function measured in 111 renal dynamic scintigraphies performed either with 99mTc-DTPA (55 studies) or with 99mTc-EC (56 studies) were compared with the relative functi...

The clinical significance of pentavalent technetium-99m dimercaptosuccinic acid (99mTc(V)-DMSA) scintigraphy in diagnosing inflammatory bowel disease (IBD) has not yet been fully elucidated. The aim of this prospective paper was to study the above. This study included 54 patients, 22 females and 32 males (mean age: 36.68±11.49; range: 18-63 years) with IBD who came to our clinics for follow-up ...

INTRODUCTION Due to limitation of colonoscopy in assessing the entire bowel and patients' intolerance in inflammatory bowel disease (IBD), in the current study, we aimed to prospectively compare the accuracy of 99mTc(V)-dimercaptosuccinic acid (DMSA) and fecal calprotectin with ileocolonoscopy as new methods for localizing inflammations. METHODS Current prospective study conducted between 2012 ...

Hellenic Journal of Nuclear Medicine • September December 2009 291 To the Editor: The Hell J Nucl Med has printed an article comparing technetium-99m pentavalentdimercapto succinic acid (99mTc(V)-DMSA) as an effective agent diagnosing acute bone and joint infection [1]. We now report that 99mTc(V)-DMSA can identify foci of infection in a case of fever of unknown origin. 99mTc(V)-DMSA, as a tumo...

Renal osteodystrophy (ROD) is a common and serious complication for uremic patients and patients are treated with 1,25-dihydroxyvitamin D3. The bone scanning agent 99mTc-phosphate has also been used to evaluate in ROD but it is not clear that bone scintigraphy has a role in the follow-up of treatment. In this study 99mTc(V)-DMSA scintigraphy was performed in eleven patients [age 40.7 +/- 17.3 (...

Background: Bone sarcomas are usually aggressive tumors treated by multimodality approaches. Early detection of residual or recurrent tumor tissue after treatment is important in the management of these patients. This is currently achieved by clinical examination, diagnostic radiological procedures, radionuclide imaging techniques and detailed histological examination. Tumor response to preoper...

introduction: medullary thyroid carcinoma (mtc) is a rare thyroid cancer secreting calcitonin (ct) which is the most sensitive and specific tumor marker for mtc. this type of thyroid cancer is able to metastasize to different body areas including regional lymph nodes, lungs, liver and bone. the aim of this study was to assess the sensitivity and specificity of [99mtc-dmsa (v)] whole body scan (...

Purified field bean protease inhibitor (FBPI) was labeled with 99mTcO4- to ascertain its ability to locate tumors in tumor-bearing rat models. The labeling was done with Sn2+ as a reducing agent and the yield was 95%. It was stable for 2 hr at ambient temperature. The biodistribution study of the intravenously injected radiolabeled FBPI in normal Wistar rats at various time intervals showed a r...